Boston Sci Whets M & amp;A Appetite with EMcision Buy

Boston Scientific could be very busy with M&A this year. During the Marlborough, MA-based company’s most recent earnings call, CEO Michael Mahoney hinted at the possibility of potential acquisitions. “We do have a pretty active M&A appetite,” Mahoney said, according to a transcript from Seeking Alpha. "So, I think you'll see us be active with tuck-in acquisitions to strengthen our category leadership strategy." On Monday, Boston Scientific backed up its CEO’s words and revealed it would strengthen its endoscopy offerings with the acquisition of London – based EMcision, for an undisclosed sum. With the EMcision acquisition the Marlborough, MA-based company will gain access to the Habib EndoHPB probe, an endoscopic bipolar radiofrequency device. The technology has received FDA clearance and CE mark and is used by physicians in the treatment and palliative care of patients living with pancreaticobiliary cancers. Patients with pancreaticobiliary cancers often develop jaundice as a result of tissue ingrowth that blocks ducts that enable bile to drain out of the GI tract. The Habib EndoHPB probe coagulates this tissue to help ensure that the fluids are able to drain, which can result in an improvement in a patient's quality of life. In addition to coagulating tissue, physicians will frequently place stents to ensure that the GI tract remains open during palliative care. Don't miss the Advanced Design and Manufacturing Conference and Expo...
Source: MDDI - Category: Medical Devices Authors: Tags: Medical Device Business Source Type: news

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Publication date: Available online 10 November 2019Source: Science &SportsAuthor(s): X. BigardRésuméObjectifsLa nutrition joue un rôle indéniable pour l’excellence des performances dans les sports d’endurance. Les réserves en glucose de l’organisme sous forme de glycogène étant limitées, toute épargne du glycogène et tout substrat alternatif au glucose peuvent être utiles pour les performances. C’est ainsi que ces dernières années, les stratégies nutritionnelles destinées à augmenter la ...
Source: Science and Sports - Category: Sports Medicine Source Type: research
Would it be possible to do Child Psych --> Peds Palliative? I am assuming the answer is no but I was curious about whether there is any possible way to make this happen without triple boarding. Thanks!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Hospice and Palliative Medicine Source Type: forums
I Built My Identity Around Being Bipolar. Then My Doctor Said I’m Not Bipolar What happens when what’s wrong with you isn’t what’s wrong with you? www.phillymag.com Thoughts?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
ConclusionsMRI may offer more superior diagnostic performance than CT for detecting T3-4 disease and EMVI, thereby supporting its alternative application to CT in local staging of colon cancer.
Source: European Journal of Radiology - Category: Radiology Source Type: research
tro V Abstract Immunotherapy has been showed as a promisor treatment, in special for hematological diseases. Chimeric antigen receptor T cells (CARs) which are showing satisfactory results in early-phase cancer clinical trials can be highlighted. However, preclinical models are critical steps prior to clinical trial. In this way, a well-established preclinical model is an important key in order to confirm the proof of principle. For this purpose, in this chapter will be pointed the methods to generate tumor cells expressing firefly Luciferase. In turn, these modified cells will be used to create a subcutaneous and...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract Chimeric antigen receptor (CAR) T cell therapies are ex vivo manufactured cellular products that have been useful in the treatment of blood cancers and solid tumors. The quality of the final cellular product is influenced by several amenable factors during the manufacturing process. This review discusses several of the influences on cell product phenotype, including the raw starting material, methods of activation and transduction, and culture supplementation. PMID: 31707678 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
m KCR Abstract CAR-T cell immunotherapy is a promising therapeutic modality for cancer patients. The success of CAR-T cell therapy has been associated with the phenotype, activation and functional profiling of infused CAR-T cells. Therefore, immunophenotypic characterization of CAR-T cells during bioprocess is crucial for cell quality control and ultimately for improved antitumor efficacy. In this chapter, we propose a flow cytometry panel to characterize the immunophenotype of the CAR-T subsets. PMID: 31707677 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract Lentiviral vectors are being used in a growing number of clinical applications, including T cell immunotherapy for cancer. As this new technology moves forward, a safety concern is the inadvertent recombination and subsequent development of a replication-competent lentivirus (RCL) during the manufacture of the vector material. To assess this risk, regulators have required screening of T cell products infused into patients for RCL. Since vector particles have many of the proteins and nucleotide sequences found in RCL, a biologic assay has proven the most sensitive method for RCL detection. As regulators ha...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract Adoptive immunotherapy of cancer using T cells expressing chimeric antigen receptors (CARs) is now an approved treatment for non-Hodgkin lymphoma (NHL) and B cell acute lymphoblastic leukemia (B-ALL), inducing high response rates in patients. The infusion products are generated by using retro- or lentiviral transduction to induce CAR expression in T cells followed by an in vitro expansion protocol. However, use of viral vectors is cumbersome and is associated with increased costs due to the required high titers, replication-competent retrovirus (RCR) detection and production/use in a biosafety level 2 cul...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract Chimeric antigen receptor (CAR) cancer immunotherapy uses autologous immune system's cells, genetically modified, to reinforce the immune system against cancer cells. Genetic modification is usually mediated via viral transfection, despite the risk of insertional oncogenesis and off target side effects. In vitro-transcribed (IVT)-mRNA-mediated transfection could contribute to a much safer CAR therapy, since IVT-mRNA leaves no ultimate genetic residue in recipient cells. In this chapter, the IVT-mRNA generation procedure is described, from the selection of the target of the CAR T-cells, the cloning of the ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
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