Does Endothelin-1 Raise or Lower Blood Pressure in Humans?

Conclusion: Alternatively, hypertension could be attributed to renal actions of ET-1. Either of these pathophysiological actions may explain a hypertensive role of ET-1 despite a lower risk of hypertension associated with the G allele at rs9349379, the common SNP in thePHACTR1 gene that is a distal regulator ofEDN1 and leads to an increased expression of ET-1.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research