98PEffect of prolactin receptor antagonist in different cancer models

Background: Increased levels of Prolactin (Prl) receptors have been found in endocrine dependent cancers e.g. breast and prostate cancer as well as in ovarian cancer and glioblastomas. Prl stimulates cell growth by activating the intracellular JAK-STAT pathway. A new line of research in the last years suggest that human cytomegalovirus (CMV) infection can also contribute to several human malignancies including glioblastoma brain tumor and ovarian cancer. A supportive study, showed that CMV DNA was present in 50% of fresh ovarian carcinoma tissue samples (39 samples). It was suggested that human CMV is able to create a more malignant phenotype of tumor cells by the action of its regulatory proteins and non-coding RNA, which will affect their proliferation, invasion of other tissues, survival and other cellular properties. Furthermore, prolactin receptor expression and circulating prolactin levels have been shown to be higher among women with ovarian cancer vs. benign-condition or healthy control.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research