Advances in glycosylation-mediated cancer-targeted drug delivery.

Advances in glycosylation-mediated cancer-targeted drug delivery.
Drug Discov Today. 2018 Feb 28;:
Authors: Cai L, Gu Z, Zhong J, Wen D, Chen G, He L, Wu J, Gu Z
Abstract
To enhance efficacy and safety, therapeutic antitumor agents are expected to target the desired locations where the ligand-receptor binding acts as a typical recognition approach. Among the various ligands, carbohydrates represent a crucial structure of tumor cell membranes and have been shown effective for cell-selective drug delivery. Recently, glycosylation-mediated therapeutic targeting strategies have been increasingly developed to form a variety of nanoscale delivery carriers. In this review, a variety of glycosylated drug delivery systems and their applications for cancer therapy have been surveyed. The future perspectives, including opportunities and challenges in this field, are also discussed.
PMID: 29501708 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - February 28, 2018 Category: Drugs & Pharmacology Authors: Cai L, Gu Z, Zhong J, Wen D, Chen G, He L, Wu J, Gu Z Tags: Drug Discov Today Source Type: research