ESNR survey taps into future of imaging for dementia

VIENNA - While there is considerable consensus on which modalities and protocols...Read more on AuntMinnie.comRelated Reading: MRI shows physical activity can slow dementia, Alzheimer's MR scans may detect signs of early dementia in elderly MRI, PiB-PET may help distinguish dementias
Source: Headlines - Category: Radiology Source Type: news

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DiscussionOur study demonstrated the robustness of a multisite Centiloid [11C]PIB-PET study and established a range of pathology-based CL thresholds.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
CONCLUSIONS: Our analysis on these individuals lead to several interesting observations together suggesting that AD risk factors comprise a network of interlocking feedback loops that may be modifiable. Our findings indicate previously unidentified connectivity between AD risk factors, suggesting that treatment regimens should be tailored to the individual and multi-modal to simultaneously return several risk factors to a normative state. If successfully performed, the possibility to slow progression of AD and possibly reverse aspects of cognitive decline may become achievable. PMID: 30338750 [PubMed - as supplied by publisher]
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research
This study is part of a growing body of research that suggests a sleep-deprived brain might be more vulnerable to Alzheimer’s disease. Animal studies have shown levels of plaque-forming A-beta plummet during sleep. Other research points to the fact that a sleeping brain runs the “clean cycle” (a reference to a dishwasher) to remove the day’s metabolic debris, specifically A-beta plaques. A study done in 2017 found that even one sleepless night appears to leave behind an excess of the troublesome protein fragment. While this is all impressive research, scientists believe there are still plenty of gap...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Health-related Mental Health and Wellness Research Sleep Alzheimer's disease Dementia Source Type: blogs
Conclusions: By approaching both intra- and interregional intrinsic brain activities in the early stages of AD, the findings of this research provide insights into the early pathogenesis of AD as related to memory performance.Dement Geriatr Cogn Disord 2018;46:229 –242
Source: Dementia and Geriatric Cognitive Disorders - Category: Geriatrics Source Type: research
Dutch researchers have developed a quantitative method of analyzing PET images...Read more on AuntMinnie.comRelated Reading: Are amyloid PET scans ready for the clinical setting? PiB-PET study strengthens link between amyloid, dementia How do seniors react to amyloid-PET results? High amyloid levels on PET may indicate early Alzheimer's PET links midlife vascular risk factors to more amyloid
Source: Headlines - Category: Radiology Source Type: news
In this study, we investigated the feasibility to reduce the PET dose without a significant loss of quantitative accuracy in 3D dynamic row action maximum likelihood algorithm-reconstructed PET images using [11C]PIB and [18F]THK5351. Eighteen cognitively normal young controls, cognitively normal elderly controls, and patients with probable Alzheimer ’s disease (n = 6 each), were included. Reduced doses were simulated by randomly sampling half and quarter of the full counts in list mode data for one independent realization at each simulated dose. Bias was evaluated between the reduced dose from the full ...
Source: Radiological Physics and Technology - Category: Physics Source Type: research
DiscussionADNI publications from 2016 and 2017 supported the idea of AD as a multifactorial disease and provided insights into the complexities of AD disease progression. These findings guided the development of novel biomarkers and suggested that subject selection on the basis of multiple factors may lower AD clinical trial costs and duration. The use of multiple concurrent therapies in these trials may prove more effective in reversing AD disease progression.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Conclusion: WM binding increases with age and varies with GM 11C-PiB. These correlations should be considered when using WM for normalization in 11C-PiB PET studies. The cerebellar crus1+crus2 showed no increase with age and cerebellar GM+WM showed minimal increase, supporting their use as reference regions for cross-sectional studies comparing wide age spans. In longitudinal studies, the increase in WM uptake may be minimal in the short-term and thus using WM as a reference region in these studies seems reasonable. However, as participants age, the findings may be affected by changes in WM uptake. Changes in WM 11C-PiB up...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
Publication date: Available online 19 September 2018Source: NeuroImage: ClinicalAuthor(s): Stefan Klöppel, Shan Yang, Elias Kellner, Marco Reisert, Bernhard Heimbach, Horst Urbach, Jennifer Linn, Stefan Weidauer, Tamara Andres, Maximilian Bröse, Jacob Lahr, Niklas Lützen, Philipp T. Meyer, Jessica Peter, Ahmed Abdulkadir, Sabine Hellwig, Karl Egger, for the Alzheimer's Disease Neuroimaging InitiativeAbstractThe identification of pathological atrophy in MRI scans requires specialized training, which is scarce outside dedicated centers. We sought to investigate the clinical usefulness of computer-generated rep...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Authors: Kim Y, Rosenberg P, Oh E Abstract BACKGROUND: Molecular imaging of brain amyloid for the diagnosis of Alzheimer's disease (AD) using positron emission tomography (PET) has been approved for use in clinical practice by the Food and Drug Administration (FDA) since 2012. However, the clinical utility and diagnostic impact of amyloid PET imaging remain controversial. We conducted a review of the recent studies investigating clinical utility of amyloid PET imaging with focus on changes in diagnosis, diagnostic confidence, and patient management. SUMMARY: A total of 16 studies were included in the final anal...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
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