Continuous manufacturing and analytical characterization of fixed-dose, multilayer orodispersible films.

In conclusion, it was feasible to produce fixed-dose combinations in therapeutic doses up to 9 mg HCT and 3.5 mg EM for the double-layer film with adequate mechanical properties, which enable coiling up onto jumbo rolls directly after production. The best separation of the two APIs was achieved by casting a double-layer ODF consisting of different film forming polymers, which can be beneficial when processing two incompatible APIs. PMID: 29499348 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29499348?dopt=Abstract

Source: European Journal of Pharmaceutical Sciences - February 27, 2018 Category: Drugs & Pharmacology Authors: Thabet Y, Lunter D, Breitkreutz J Tags: Eur J Pharm Sci Source Type: research