Discovery of a novel multifunctional carbazole –aminoquinoline dimer for Alzheimer's disease: copper selective chelation, anti-amyloid aggregation, and neuroprotection

AbstractA novel multifunctional carbazole –aminoquinoline dimerPZ001 was designed, synthesized, and evaluated. The results indicated thatPZ001 possessed selective copper chelation, and inhibited copper-induced A β1 –42 aggregation. Furthermore,PZ001 exerted powerful neuroprotection against glutamate-induced HT22 cell death. These results suggest thatPZ001 may be a promising multifunctional anti-AD compound.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research