Correlation of Patient- and Physician-Scored Dysphagia with Videofluoroscopies in Patients Treated with Radiotherapy for Head and Neck Cancer

AbstractThe aim of this study was to investigate the correlation between patient-scored dysphagia and physician-scored dysphagia in head and neck cancer patients treated with radiotherapy. Furthermore, we wanted to compare both patient- and physician-scored dysphagia with dysphagia evaluated on swallowing videofluoroscopies. Sixty-three patients from two different centers treated with radiotherapy for head and neck cancer were evaluated in the current study. Swallowing videofluoroscopies at baseline, 6, and 12  months following radiotherapy were evaluated by 2 observers using the Penetration Aspiration Scale (PAS) and Swallowing Performance Status Scale (SPS) and correlated with patient and physician scored dysphagia. We observed a significant association between physician and patient scored dysphagia (p 
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

Related Links:

Publication date: Available online 12 December 2018Source: Radiation Physics and ChemistryAuthor(s): Shichao Wang, Lin Zhou, Jianxin Xue, Jie Lan, Lei Deng, Tingwu Yi, You LuAbstractPurposeTo compare the fixed-beam intensity-modulated radiotherapy (IMRT) with the volumetric-modulated arc therapy (VMAT) plans for different cancers using the biologically effective dose (BED).MethodsRecruited patients were divided into three groups in terms of tumor anatomic site, including head and neck, thoracic, and abdominal cancers. All of plans were generated using the fixed-beam IMRT and the VMAT techniques. The qualities of the plans ...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
Publication date: Available online 14 December 2018Source: European Journal of RadiologyAuthor(s): Dominik Deniffel, Andreas Sauter, Julia Dangelmaier, Alexander Fingerle, Ernst J. Rummeny, Daniela PfeifferABSTRACTIntroductionTo investigate the utility of quantitative dual-energy spectral CT derived iodine concentration (IC), in comparison with conventional CT attenuation, for the differentiation of pulmonary metastases from different primary malignancies.Materials and MethodsCT scans were performed on a dual-layer spectral CT. We retrospectively evaluated pulmonary metastases of 130 patients (77 men and 53 women, mean age...
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsCXPA is an uncommon, high-grade malignant tumor with highly aggressive biologic behavior. Its occurrence in such sites as the soft palate is rare and cause diagnostic difficulties. In this case, a benign pleomorphic adenoma became complicated because of lack of adequate management and the poor choices made by the patient. It underwent high-grade malignant changes and metastasized to various organs of the body, ultimately resulting in the death of the patient.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Authors: Xiao M, Liu L, Zhang S, Yang X, Wang Y Abstract Several putative biomarkers have been reported to identify cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC). Herein, we aimed to demonstrate the validity and the underlying relationship for these biomarkers in HNSCC. Bioinformatic analyses for the reported CSC biomarkers of HNSCC were performed based on the TCGA primary HNSCC cohort using the UCSC Xena browser. Targeted strategies for the validated biomarkers were searched and summarized. A total of 27 reported CSC biomarkers for HNSCC were identified and comprehensivel...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Shoji M, Qian WP, Nagaraju GP, Brat DJ, Pessolano D, Luzietti R, Chennamadhavuni S, Yamaguchi M, Yang L, Liotta DC Abstract Synthetic monocarbonyl analogs of curcumin (MACs) are cytotoxic against several cancers including head and neck cancer, pancreatic cancer, colon cancer, and breast cancer. Mechanisms of action include depolarization of the mitochondrial membrane potential and inhibition of NF-κB, leading to apoptosis. We previously demonstrated that UBS109 (MAC), has preventive effects on bone loss induced by breast cancer cell lines. We determined whether UBS109 could inhibit and prevent lung m...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusions: Although the quality registration was only recently launched, it already visualizes hospital variation in current care. Four determinants were found to be influential: tumor stage, performance status, tumor site, and volume. More data are needed to assure stable results for use in quality improvement. PMID: 30545996 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Abstract Since their discovery as the etiologic agents of cervical cancer in the mid-1970s, human papillomaviruses (HPVs) have been linked with a growing number of epithelial-derived tumors, including head and neck squamous cell carcinomas. HPV demonstrates a particular predilection for causing tumors of the oropharynx, with the majority of cases involving infection with high-oncogenic risk HPV-16. People living with HIV are at increased risk of infection with HPV- and HPV-related oral complications even with adequate control of their HIV infection with antiretroviral therapy. In this chapter, we discuss the molec...
Source: Cell Research - Category: Cytology Authors: Tags: Cancer Treat Res Source Type: research
We present a case of CXPA arising in the soft palate in a 35-year-old female patient.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Perineural invasion (PNI), the neoplastic invasion of nerves, is a common pathological finding in head and neck cancer that is associated with poor clinical outcomes. PNI is a histological finding of tumor cell infiltration and is distinct from perineural tumor spread (PNTS), which is macroscopic tumor involvement along a nerve extending from the primary tumor that is by definition more advanced, being radiologically or clinically apparent. Despite widespread acknowledgement of the prognostic significance of PNI/PNTS, the mechanisms underlying its pathogenesis remain largely unknown, and specific therapies targeting nerve ...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Critical Review Source Type: research
CONCLUSIONS: Lesions of the head and neck, those removed in primary care and with increased tumour thickness were more likely to have positive margins following surgical excision. Close margins were associated with excision in primary care and female gender. The value of re-excising tumours with close margins remains uncertain. PMID: 30543608 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
More News: Cancer | Cancer & Oncology | Head and Neck Cancer | Speech-Language Pathology | Study