Polygenic Risk Score for Alzheimer's Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life.

CONCLUSIONS: Genetic risk for Alzheimer's disease may affect early-life cognition and hippocampal volumes, as shown in two independent samples. These data support previous evidence that some forms of late-life dementia may represent developmental conditions with roots in childhood. This result may vary depending on a sample's genetic risk and may be specific to some types of memory tasks.
PMID: 29495896 [PubMed - as supplied by publisher]

Source: The American Journal of Psychiatry - March 2, 2018 Category: Psychiatry Authors: Axelrud LK, Santoro ML, Pine DS, Talarico F, Gadelha A, Manfro GG, Pan PM, Jackowski A, Picon F, Brietzke E, Grassi-Oliveira R, Bressan RA, Miguel EC, Rohde LA, Hakonarson H, Pausova Z, Belangero S, Paus T, Salum GA Tags: Am J Psychiatry Source Type: research