Correction to: Hypothermic Machine Preservation of the Liver: State of the Art

AbstractThe article Hypothermic Machine Preservation of the Liver: State of the Art, written by Andrea Schlegel, Xavier Muller, and Philipp Dutkowski, was originally published electronically on the publisher ’s internet portal (currently SpringerLink) on January 22, 2018, without open access.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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ConclusionsThe findings showed that CPR is not independently associated with long-term outcomes after liver transplantation for HCC.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
In this study, we evaluate complete blood count based inflammatory markers in hepatocellular carcinoma (HCC) to predict overall and recurrence-free survival of patients after liver transplant. Between 2001 and 2017, all HCC indicated liver transplants were retrospectively reviewed. Inclusion criteria included presence of complete blood cell counts with differential within three months prior to transplantation. Exclusion criteria included retransplantation and inadequate posttransplant followup. A total of 160 patients with HCC were included in the study. Of those, 74.4% had hepatitis C virus as the underlying cause of HCC....
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
AbstractSinusoidal obstruction syndrome (SOS) is a rare liver disorder due to hepatic vascular injury. Its rapid and accurate diagnosis is crucial for patient survival. SOS is often established clinically, based on Baltimore, modified Seattle, or European Society for Blood and Marrow Transplantation (EBMT) criteria. Unfortunately, such criteria are not highly specificity and fail to provide a timely, reliable differential diagnosis. The use of noninvasive imaging techniques, such as ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and fluorodeoxyglucose positron emission tomography/computed tomo...
Source: Insights into Imaging - Category: Radiology Source Type: research
Condition:   Hepatocellular Carcinoma Interventions:   Drug: Lenvatinib;   Drug: Placebo;   Drug: Immunosuppressive regimen Sponsor:   RenJi Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
When the only hope for Lubna Siddiqui's critically-ill toddler, Fatima, was a liver transplant, Lisa Wilson's son, Tom, 22, saved her life through organ donation after he died.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Liver transplantation (LTx) is currently the most powerful treatment for end-stage liver disease. Although liver allograft is more tolerogenic compared to other solid organs, the majority of LTx recipients still require long-term immune suppression (IS) to control the undesired alloimmune responses, which can lead to severe side effects. Thus, understanding the mechanism of liver transplant tolerance and crosstalk between immune cells, especially alloreactive T cells and liver cells, can shed light on more specific tolerance induction strategies for future clinical translation. In this review, we focus on alloreactive T ce...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Graft-versus-host disease (GVHD) is one of the most common complications after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) [1]. It remains a significant cause of treatment failure, resulting in mortality> 20% and morbidity> 50% of transplant recipients [2]. Acute GVHD (aGVHD) is mediated by alloreactive immunocompetent donor T cells as well as the delivery of proinflammatory cytokines which induce damage in target organs such as skin, liver or gastrointestinal tract. [3 –4]
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Worldwide, the prevalence of alcohol use disorder (AUD) is 20 –30% in men and 10–15% in women, and cirrhosis due to alcohol-related liver disease (ALD) is responsible for 0.9% of global deaths and 47.9% of cirrhosis-related deaths. End-stage ALD (ESALD) is the final condition of alcohol-related cirrhosis, and severe acute alcohol-related hepatitis (SAAH) i s a distinct clinical syndrome associated with the consumption of large amounts of alcohol. In some cases, ESALD, and SAAH may need liver transplantation (LT).
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Guidelines Source Type: research
Premalatha Pushpanathan, Gifty Sara Mathew, Sribal Selvarajan, Krishna G Seshadri, Padma SrikanthIndian Journal of Medical Microbiology 2019 37(2):268-277 Gut microbiota are microorganisms that inhabit the gut; they coexist peacefully with the host, thereby contributing to the health and well-being of individuals. Bacteroidetes and Firmicutes largely dominate the gut microbial flora. The intestinal flora promotes intestinal mucosal integrity, provides essential nutrients such as vitamins and enzymes, protects the body against pathogens and produces antimicrobial peptides such as defensins, C-type lectins, cathelicidins, t...
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
AbstractPurpose of reviewIn this review article, we evaluate sex differences in the natural history of NAFLD and highlight distinct risk profiles of women with NAFLD, as well as unique treatment considerations and research gaps.Summary of FindingsReproductive factors, such as menopausal status, should be considered when evaluating NAFLD risk in women, as well as additional reproductive risk factors such as age at menarche, presence of polycystic ovary syndrome, and gestational diabetes. Women do appear to have lower risk for hepatocellular carcinoma from NASH, as well as lower mortality from NASH cirrhosis than men, althou...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
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