Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes.

Conclusion: Here, we discuss 1) the molecular basis underlying transcription of telomeric ESs and VSG antigenic switching; 2) the current knowledge of VSG monoallelic expression; 3) the role of inositol phosphate pathway in the regulation of VSG expression and switching; and 4) the developmental regulation of Pol I transcription of procyclin and VSG genes.
PMID: 29491740 [PubMed]

Source: Current Genomics - March 3, 2018 Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research