Triple advantages of injectable long acting second generation antipsychotics: Relapse prevention, neuroprotection, and lower mortality

The worst outcome for any medical disorder is death, followed closely by severe functional disability. Persons with schizophrenia suffer from high rates of both.
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research

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 Suicide is something that most people think they understand, but there are many misconceptions about it. We say it’s a serious problem, yet will mention it casually and insensitively in certain settings. In this episode, our hosts openly discuss suicide and their personal stories with trying to end their own lives.   SUBSCRIBE &REVIEW “I thought about suicide every day for as far back as I can remember.” – Gabe Howard   Highlights From ‘Suicide’ Episode [1:00] Frankly discussing suicide. [3:00] Don’t belittle a person’s suicide attempt. [7:00] Why ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Depression Schizophrenia Suicide Source Type: blogs
 Life is tough. Life with mental illness is tougher. Life with mental illness on top of other conditions and life experiences can seem too tough. Today’s guest shares how she dealt with Tourette Syndrome, OCD, anxiety, depression, and many other things, by tapping into her own super powers. Perhaps you can, too. Subscribe to Our Show! And Remember to Review Us! About Our Guest Everyone has challenges but some people have more than others. Brett Francis knows this from personal experience. Only now she turns those challenges—her own and other people’s—into assets. Her mantra is ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General OCD Self-Help The Psych Central Show anxiety Gabe Howard Tics Tourette Syndrome Vincent M. Wales Source Type: blogs
Persons with schizophrenia (SZ) have life expectancies that are 15-20 years shorter than the general population, primarily due to cardiovascular-related deaths. In addition to premature mortality, persons with SZ have high rates of disability largely due to cognitive deficits. While cardiometabolic risk as well as cognition are known to be associated with poor sleep and inflammation in the general population, this has not been systematically examined in persons with SZ, although SZ is associated with inflammatory pathology and sleep disturbances that predate the use of antipsychotic medications and accumulation of poor lifestyle habits.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Poster Number: EI - 52 Source Type: research
A person should not be defined by an illness or condition.  Often in popular media or casual conversation, people speak about the subject of a news story or an acquaintance by saying, “he is bipolar”, “schizophrenic”, or “mentally ill.” No one says, “She is cancer,” “she is a heart condition,” or “she is lupus.” Aside from a few very select common physical illnesses, such as diabetes where people find community and comfort in sharing their diagnosis, we would never consider insulting a person by simply identifying them by the disease which they ha...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Mental Health and Wellness Minding the Media Stigma Crisis Counseling destigmatization discrimination Labels neurodivergent Stereotypes Validation Source Type: blogs
Publication date: 19 February 2019Source: Cell Reports, Volume 26, Issue 8Author(s): Elizabeth C. Davenport, Blanka R. Szulc, James Drew, James Taylor, Toby Morgan, Nathalie F. Higgs, Guillermo López-Doménech, Josef T. KittlerSummaryAltered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and neurodevelopmental disorders, but the underlying genetic etiology remains poorly understood. Copy number variations in CYFIP1 are associated with autism, schizophrenia, and intellectual disability, but its role in regulating synaptic inhibition or E/I balance remains unclear. We show that CYFIP1, and...
Source: Cell Reports - Category: Cytology Source Type: research
Contributors : Galina Apostolova ; Georg DechantSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring CNS development, the nuclear protein SATB2 is expressed in superficial cortical layers and determines projection neuron identity. In the adult CNS, SATB2 is expressed in pyramidal neurons of all cortical layers and is a regulator of synaptic plasticity and long-term memory. Common variation in SATB2 locus confers risk of schizophrenia whereas rare, de novo structural and single nucleotide variants cause severe intellectual disability and absent or limited speech. To which extent symp...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Discussion Bipolar disorder (BD) is a chronic, recurrent, affective disorder with fluctuations in energy and mood. “Bipolar disorder, previously known as manic depressive illness, is a severe chronic mood disorder characterized by episodes [note not just one instance] of mania, hypomania, and alternating or intertwining episodes of depression.” Affective disorders are classified based on their severity and extent, from unipolar to BDII to BDI. “Individuals with unipolar disorder present with depressive episodes only, and those with bipolar II or I disorder show increasingly pronounced episodes of mood ele...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Publication date: Available online 16 February 2019Source: Neuroscience LettersAuthor(s): Ruoqi Gao, Colleen R. Zaccard, Lauren P. Shapiro, Leonardo E. Dionisio, Maria Dolores Martin-de-Saavedra, Nicolas H. Piguel, Christopher P. Pratt, Katherine E. Horan, Peter PenzesAbstractGABAergic interneurons are emerging as prominent substrates in the pathophysiology of multiple neurodevelopmental disorders, including autism spectrum disorders, schizophrenia, intellectual disability, and epilepsy. Interneuron excitatory activity is influenced by 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid receptors (AMPARs), which in...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
CONCLUSIONS: CNVs implicated in neurodevelopmental disorders, including schizophrenia, are associated with cognitive deficits, even among unaffected individuals. These deficits may be subtle but CNV carriers have significant disadvantages in educational attainment and ability to earn income in adult life.Declaration of interestNone. PMID: 30767844 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Schizophrenia continues to be one of the lesser understood disorders of brain development. It is generally believed to involve both genetic and environmental influence and shares many risk factors with other brain disorders such as autism and intellectual disability. However, determining the exact path schizophrenia follows is difficult, to say the least. In an August 2018 study, researchers gathered enough data to describe brain development patterns associated with schizophrenia. Specifically, results indicated that parts of the brain’s cortex, which is the outermost layer of neural tissue in the brain, develop diff...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Research Schizophrenia Neuroscience Psychosis Source Type: blogs
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