Antibody Responses to Citrullinated and Noncitrullinated Antigens in the Sputum of Subjects With Rheumatoid Arthritis and Subjects at Risk for Development of Rheumatoid Arthritis

ConclusionThese findings suggest that sputum antibody reactivity to particular citrullinated and noncitrullinated proteins/peptides is specific for RA and for subjects at risk of RA, and the association of these proteins/peptides with NETs may be a key feature of early RA–related autoimmunity in the lung. These results further support the hypothesis that the lung plays a role in early RA–related autoimmunity.

Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: M. Kristen Demoruelle, Emily Bowers, Lauren J. Lahey, Jeremy Sokolove, Monica Purmalek, Nickie L. Seto, Michael H. Weisman, Jill M. Norris, Mariana J. Kaplan, V. Michael Holers, William H. Robinson, Kevin D. Deane Tags: Original Article Source Type: research