A CD8 α‐ Subset of CD4+SLAMF7+ Cytotoxic T Cells is Expanded in Patients with IgG4‐Related Disease and Decreases following Glucocorticoid Treatment

ConclusionsA subset of CD8α‐CD4+SLAMF7+ cytotoxic TEM cells is oligoclonally expanded in patients with active IgG4‐RD. This population contracts following glucocorticoid‐induced remission. Further characterization of this cell population may provide prognostic information and targets for therapeutic intervention.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: Emanuel Della ‐Torre, Emanuele Bozzalla‐Cassione, Clara Sciorati, Eliana Ruggiero, Marco Lanzillotta, Silvia Bonfiglio, Hamid Mattoo, Cory A. Perugino, Enrica Bozzolo, Lucrezia Rovati, Paolo Giorgio Arcidiacono, Gianpaolo Balzano, Dejan Lazarevic, Chi Tags: Full Length Source Type: research