Ranibizumab Safe, Effective for Macular Edema Due to Uncommon Causes Ranibizumab Safe, Effective for Macular Edema Due to Uncommon Causes

Ranibizumab 0.5 mg is safe and effective for patients with macular edema (ME) that is not due to diabetes, retinal vein occlusion (RVO) or neovascular age-related macular degeneration (nAMD), according to findings from the PROMETHEUS randomized trial.Reuters Health Information
Source: Medscape Ophthalmology Headlines - Category: Opthalmology Tags: Ophthalmology News Source Type: news

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CONCLUSIONS: AMD, cataract and DRED but not glaucoma are associated with an increased risk of dementia. Individuals with both ophthalmic and systemic conditions are at higher risk of dementia compared with those with an ophthalmic or systemic condition only.PMID:34518160 | DOI:10.1136/bjophthalmol-2021-319508
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
People with macular degeneration, cataracts and diabetes-related eye disease at greater riskMillions of people with eye conditions including age-related macular degeneration, cataracts and diabetes-related eye disease have an increased risk of developing dementia, new research shows.Vision impairment can be one of the first signs of the disease, which is predicted to affect more than 130 million people worldwide by 2050.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Health Dementia Blindness and visual impairment Society Source Type: news
AbbVie and REGENXBIO form a strategic partnership combining eye care and gene therapy expertise Companies will develop and commercialize RGX-314, an investigational gene therapy for wet age-related macular degeneration, diabetic retinopathy and other ch... Biopharmaceuticals, Regenerative Medicine, Ophthalmology AbbVie, REGENXBIO, gene therapy, macular degeneration, diabetic retinopathy
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
The German pharma giant is working with top eye hospitals in the country to support virtual care for patients with Diabetic Macular Edema or age-related macular degeneration.
Source: mobihealthnews - Category: Information Technology Source Type: news
Eur J Ophthalmol. 2021 Sep 2:11206721211042554. doi: 10.1177/11206721211042554. Online ahead of print.ABSTRACTOptical coherence tomography angiography (OCTA) is a non-invasive tool to assess the retino-choroidal vasculature in vivo. It tracks the red blood cell movement and maps the vasculature in quick succession. In routine, diabetic retinopathy, age related macular degeneration, central serous chorioretinopathy, and others are commonly being studied to unveil its clinic role. On the other hand, amblyopia is a condition where the visual acuity is subnormal due to non-organic causes in the eye. But the OCTA studies till n...
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Conclusion: Outcomes were similar between patients with neovascular age-related macular degeneration treated with an intravitreal aflibercept early-T&E or late-T&E regimen after initial dosing, with one injection difference over 2 years. Trial Registration: ClinicalTrials.gov Identifier: NCT02581891 https://clinicaltrials.gov/ct2/show/NCT02581891. Supplemental Digital Contents (files 1 http://links.lww.com/IAE/B419).
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
This study sought to investigate the temporal protein expression changes that occur in a human induced pluripotent stem cell (iPSC)-based RPE-EMT model. We utilized multiplexed isobaric tandem mass tag (TMT) labeling followed by high-resolution tandem mass spectrometry for precise and in-depth quantification of the RPE-EMT proteome. We have identified and quantifed 7,937 protein groups in our TMT-based mass spectrometry analysis. We observed a total of 532 proteins that are differentially regulated during RPE-EMT. Further, we integrated our proteomic data with prior transcriptomic (RNA-seq) data to provide additional insig...
Source: Molecular and Cellular Proteomics : MCP - Category: Molecular Biology Authors: Source Type: research
J Cell Mol Med. 2021 Aug 27. doi: 10.1111/jcmm.16882. Online ahead of print.ABSTRACTRetinal pigment epithelium (RPE) is a highly polarized epithelial monolayer lying between the photoreceptor layer and the Bruch membrane. It is essential for vision through participating in many critical activities, including phagocytosis of photoreceptor outer segments, recycling the visual cycle-related compounds, forming a barrier to control the transport of nutrients, ions, and water, and the removal of waste. Primary cilia are conservatively present in almost all the vertebrate cells and acts as a sensory organelle to control tissue de...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Exp Eye Res. 2021 Aug 18:108733. doi: 10.1016/j.exer.2021.108733. Online ahead of print.ABSTRACTDNA methylation is important in developing and post-mitotic cells in various tissues. Recent studies have shown that DNA methylation is highly dynamic, and plays important roles during retinal development and aging. In addition, the dynamic regulation of DNA methylation is involved in the occurrence and development of age-related macular degeneration and diabetic retinopathy and shows potential in disease diagnoses and prognoses. This review introduces the epigenetic concepts of DNA methylation and demethylation with an emphasis...
Source: Experimental Eye Research - Category: Opthalmology Authors: Source Type: research
CONCLUSION: With regard to the limited therapeutic options for choroidal ischemia, optimisation of the cardiovascular risk profile and the management of accompanying ocular and systemic diseases are essential.PMID:34416787 | DOI:10.1055/a-1402-7592
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Authors: Source Type: research
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