Ocular Surface and Tear Film Characteristics in a Sclerodermatous Chronic Graft-Versus-Host Disease Mouse Model
Purpose:
To report the characteristics of the ocular surface in a previously established sclerodermatous chronic graft-versus-host disease (cGVHD) mouse model.
Methods:
The ocular surface features and tear film parameters of the mouse model were assessed by histopathology, immunohistochemistry, electron microscopy, quantitative polymerase chain reaction, and flow cytometry.
Results:
The mice exhibited loss of body weight and decreased tear secretion (P
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research
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