50  years with Down syndrome: A longitudinal study

ConclusionsAt the age of 50, those not already diagnosed with dementia showed some decline on most tests. While this may include scores of people who subsequently develop dementia, it may also reflect the normal ageing process in this population.
Source: Journal of Applied Research in Intellectual Disabilities - Category: Disability Authors: Tags: ORIGINAL ARTICLE Source Type: research

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DISCUSSION: The German version of the CAMDEX-DS provides an internationally recognized tool for the diagnostics and monitoring of cognitive decline in Down's syndrome. Furthermore, the German version can standardize medical care of these patients. In particular it provides a means of participation in international research trials for this at risk population. PMID: 31399752 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Gerontologie und Geriatrie - Category: Geriatrics Authors: Tags: Z Gerontol Geriatr Source Type: research
American Journal on Intellectual and Developmental Disabilities,Volume 124, Issue 4, Page 354-373, July 2019.
Source: American Journal on Intellectual and Developmental Disabilities - Category: Disability Authors: Source Type: research
Abstract Older adults with Down syndrome (DS) and dementia are an emerging sub-population. With much longer life spans than decades ago, issues have arisen as to where these aging adults will live and how nurses and other staff in facilities can provide effective care to these individuals. The current article presents a research study that examined the learnings of nurses and staff members working within a western Canadian program for older adults with DS and dementia. These learnings include: the importance of learning from each other; importance of collaboration; how individuals with developmental disabilities c...
Source: Journal of Gerontological Nursing - Category: Nursing Authors: Tags: J Gerontol Nurs Source Type: research
Carla M. Startin1,2,3*, Bryony Lowe2,3, Sarah Hamburg1,2,3, Rosalyn Hithersay1,2,3, Andre Strydom1,2,3 and LonDownS Consortium 1Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom2Division of Psychiatry, University College London, London, United Kingdom3LonDownS Consortium, London, United Kingdom Down syndrome (DS) is associated with intellectual disability and an ultra-high risk of developing dementia. Informant ratings are invaluable to assess abilities and related changes in adults with DS, particularl...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
er MQ Abstract There is evidence that frontal-subcortical circuits play an important role in the initial presentation of dementia in Down syndrome (DS), including changes in behavior, a decline in working memory and executive dysfunction. We evaluated 92 individuals with DS (≥30 years of age), divided into 3 groups by diagnosis-stable cognition, prodromal dementia, and Alzheimer's disease. Each individual was evaluated with an executive protocol developed for people with intellectual disabilities and was rated for behaviors related to frontal lobe dysfunction (disinhibition, executive dysfunction, and apat...
Source: Neurobiology of Aging - Category: Geriatrics Authors: Tags: Neurobiol Aging Source Type: research
In this study, we used the Ts65Dn mouse model of DS to evaluate the beneficial effect of a DNA vaccination against the Aβ1-11 fragment, in ameliorating Aβ-related neuropathology and rescue of cognitive and behavioral abilities. Anti-Aβ1-11 vaccination induced antibody production and facilitated clearance of soluble oligomers and small extracellular inclusions of Aβ from the hippocampus and cortex of Ts65Dn mice. This was correlated with reduced neurodegeneration and restoration of the homeostatic phenotype of microglial and astroglial cells. Vaccinated Ts65Dn mice performed better in spatial-learning ta...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
CONCLUSION: The CAMDEX-DS can be considered the first valid and reliable instrument for evaluating dementia in adults with DS in Brazil. Its use in such individuals could improve clinical practice and research. PMID: 30365671 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Psiquiatria - Category: Psychiatry Authors: Tags: Rev Bras Psiquiatr Source Type: research
Journal of Intellectual Disability Research, EarlyView.
Source: Journal of Intellectual Disability Research - Category: Disability Authors: Source Type: research
AbstractDown syndrome (DS) is associated with a variety of cognitive impairments, notably memory impairments. Due to the high prevalence rates of early-onset dementia associated with DS, it is imperative to understand the comprehensive development of memory impairments beginning in childhood and into adulthood, as this may help researchers identify precursors of dementia at earlier stages of development and pinpoint targets for memory intervention. The current paper provides a systematic, developmentally focused review of the nature of memory difficulties in DS across the lifespan. Specifically, this review summarizes what...
Source: Journal of Neurodevelopmental Disorders - Category: Neurology Source Type: research
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