StatPearls Book. 2018 01 Authors: Abstract Kaposi varicelliform eruption, also called eczema herpeticum, refers to a disseminated skin infection due to a virus that usually leads to localized vesicular eruptions, occurring in a patient with an underlying cutaneous disease. Although rare, it is potentially life-threatening disorder. Herpes simplex virus is considered the main causative agent. The most commonly reported cases occur in patients with atopic dermatitis. However, it has been described in association with other skin conditions such as pemphigus foliaceus, ichthyosis vulgaris, bullous pemphigoid, Darier disease, Grover disease, Hailey-Hailey disease, dyskeratosis follicularis, mycosis fungoides, Sezary syndrome, psoriasis, pityriasis rubra pilaris, rosacea, seborrheic dermatitis, contact dermatitis (both allergic and irritant), second degree burns and skin grafts. Clinical features of Kaposi varicelliform eruption include widespread clusters of umbilicated vesicles and pustules that evolve into crusted skin erosions. The most frequently affected sites are the trunk, neck, and head. The diagnosis of Kaposi varicelliform eruption is made primarily on clinical findings. The Tzanck smear, viral cultures, skin biopsy, or detection of viral DNA by Polymerase Chain Reaction may be helpful in doubtful cases. Antiviral therapy has been effective but should be started as soon as possible after diagnosis to reduce morbidity and mortality. PMID...
Source: Herpes - Category: Infectious Diseases Tags: Book Source Type: research

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Publication date: December 2019Source: Antiviral Research, Volume 172Author(s):
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 18 November 2019Source: Antiviral ResearchAuthor(s): Wanyu Dong, Wenting Xie, Yunbo Liu, Baokun Sui, Hao Zhang, Liran Liu, Yubei Tan, Xiaohan Tong, Zhen F. Fu, Ping Yin, Liurong Fang, Guiqing PengAbstractEmerging coronaviruses (CoVs) primarily cause severe gastroenteric or respiratory diseases in humans and animals, and no approved therapeutics are currently available. Here, A9, a receptor tyrosine kinase inhibitor (RTKI) of the tyrphostin class, is identified as a robust inhibitor of transmissible gastroenteritis virus (TGEV) infection in cell-based assays. Moreover, A9 exhibited potent ...
Source: Antiviral Therapy - Category: Virology Source Type: research
This article provides an overview of common pediatric oral lesions that general dentists may encounter in everyday practice. PMID: 31735228 [PubMed - in process]
Source: Herpes - Category: Infectious Diseases Authors: Tags: Dent Clin North Am Source Type: research
Conditions:   Pain, Postoperative;   Palate; Wound;   Cicatrization Interventions:   Device: Tilapia skin;   Device: Platelet-Rich Fibrin;   Device: Hawley Retainer;   Device: Surgical Wound Dressing Sponsor:   University of Sao Paulo Recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Psoriasis;   Liver Fibrosis Interventions:   Drug: Discontinue methotrexate;   Other: Medication depends on clinical judgement Sponsor:   The University of Hong Kong Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: Available online 18 November 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Elisabetta Macerola, Anello Marcello Poma, Agnese Proietti, Rossana Romani, Liborio Torregrossa, Clara Ugolini, Teresa Rago, Paolo Vitti, Fulvio BasoloPatients with indeterminate thyroid nodules (Bethesda III and IV) are often treated with diagnostic lobectomy, which in the majority of cases represent an overtreatment. A reliable rule-out molecular test could spare patients unnecessary surgery. Stained smears of 88 indeterminate thyroid nodules with histological diagnosis of follicular-patterned tumors were selected: 3...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
By HANS DUVEFELT, MD It is well known by now that a physician’s demeanor influences the clinical response patients have to any prescribed treatment. We also know that even when nothing is prescribed, a physician’s careful listening, examination and reassurance about the normalcy of common symptoms and experiences can decrease patients’ suffering in the broadest sense of the word. This has been the bread and butter of counselors for years. People will faithfully attend and pay for weeks, months and even years of therapy visits just to have an attentive and active listener and to feel like they have a...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients Physicians Primary Care Family medicine Osler Source Type: blogs
An interaction between light ’s radiation and certain exogenous and endogenous substances can lead to the development of photoallergic and/or phototoxic dermatoses. Clinically, reactions may range from acute and self-limited to chronic and recurrent. Delays in diagnosis are not uncommon due to complex clinical presentations, broad differentials, and limited number of specialists who perform phototesting. Therefore, a critical understanding of these dermatoses is essential for accurate diagnosis and appropriate management. The epidemiology, light sources, mechanisms, clinical presentations, evaluation protocols, commo...
Source: Dermatologic Clinics - Category: Dermatology Authors: Source Type: research
Phototherapeutic modalities induce apoptosis of keratinocytes and immune cells, impact cytokine production, downregulate the IL-23/Th17 axis, and induce regulatory T cells. As in anti-IL-17 or anti-IL-23 antibody treatment, the dual action of phototherapy on skin and the immune system is likely responsible for sustained resolution of lesions in diseases such as psoriasis. In cutaneous T cell lymphoma, phototherapy may function by causing tumor cell apoptosis and eliminating the neoplastic and inflammatory infiltrate. Further research on phototherapeutic mechanisms will help advance, optimize, and refine dermatologic treatm...
Source: Dermatologic Clinics - Category: Dermatology Authors: Source Type: research
As well established for patients with chronic pain, patients suffering from chronic itch also exhibit signs of peripheral and central sensitization. This has been linked to parallel neuroplastic sensitization processes. However, for chronic itch, sensitization has not yet been systematically assessed, studied, and hence validated. This review (Prospero CRD42016043002) summarizes and meta-analytically evaluates whether sensory aberrations including sensitization for itch occur in chronic itch. Databases PubMed, Embase, and Cochrane Library were searched for studies investigating somatosensory sensitivity assessment by quant...
Source: Pain - Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
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