Effects of Estrogen in Gender-dependent Fetal Programming of Adult Cardiovascular Dysfunction.

CONCLUSION: These studies suggest that estrogen/ER may contribute to sex differences in cardiovascular response to an adverse intrauterine environment and play a significant role in modulating the cardiovascular response in adulthood. PMID: 29493455 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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In conclusion, HFD-induced hypertension is not driven by increased sympathetic neurotransmission to MA in male and female Dahl ss rats. PMID: 31731103 [PubMed - in process]
Source: Autonomic Neuroscience - Category: Neuroscience Authors: Tags: Auton Neurosci Source Type: research
The mineralocorticoid aldosterone is produced in the adrenal zona glomerulosa (ZG) under the control of the renin–angiotensin II (AngII) system. Primary aldosteronism (PA) results from renin-independent production of aldosterone and is a common cause of hypertension. PA is caused by dysregulated localization of the enzyme aldosterone synthase (Cyp11b2), which is normally restricted to the ZG. Cyp11b2 transcription and aldosterone production are predominantly regulated by AngII activation of the Gq signaling pathway. Here, we report the generation of transgenic mice with Gq-coupled designer receptors exclusively activ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
ConclusionsFuture policy in Botswana must focus on the challenges that an ageing population brings, and development of health and care system resilience for the demographic change could be a model for healthcare policy across Southern Africa.
Source: BMC Proceedings - Category: Biomedical Science Source Type: research
BOSTON (CBS) — Many middle-aged adults worry they will develop dementia but are turning to unproven strategies to reduce their risk. Looking at survey data on more than 1,000 middle-aged men and women, researchers at the University of Michigan found that nearly half believe they were at least somewhat likely to develop dementia. More than a third believed that taking supplements like fish oil and vitamin E could help prevent dementia, despite the fact that the latest research does not support those claims. Only 5 percent had discussed ways to prevent dementia, like controlling high blood pressure or diabetes and...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Dementia Dr. Mallika Marshall Source Type: news
A firm that was labeled one of Medtech’s 16 Most Promising Private Companies by Canaccord Genuity earlier this year, has strong results from a study that will help with FDA approval. LimFlow recently announced positive six-month data from the full patient cohort in its PROMISE I early feasibility study of the Percutaneous Deep Vein Arterialization (pDVA) System. The Paris-based company presented the data during the Vascular Interventional Advances [VIVA] Conference held in Las Vegas, earlier this month. The company’s technology is used for the treatment of chronic limb-threatening ischem...
Source: MDDI - Category: Medical Devices Authors: Tags: Cardiovascular Source Type: news
Real-world data suggest that patients who take ruxolitinib for myelofibrosis or polycythemia vera may develop obesity and hypertension.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
This study aims to assess the association between comorbid depression and health-promoting behavior in middle-aged and older Australian women with hypertension or hea...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
MONDAY, Nov. 18, 2019 (American Heart Association News) -- One in five women of childbearing age has high blood pressure, according to a new study that found few of these women are on a diet that could help them– and their babies–...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
HIGH blood pressure is a common condition which often goes undetected because symptoms are rarely noticeable. But if a high reading is left untreated it can lead to serious complications. The following symptoms can signal a hypertensive crisis that may be life-threatening.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractPulmonary hypertension (PH) is a complex and progressive disease characterized by increased pulmonary vascular resistance and pulmonary artery pressure, leading to pulmonary vascular remodeling, right heart failure, and ultimately death. Although several molecular pathways related to vascular remodeling have been reported, the mechanism behind this fatal disease with poor prognosis remains largely unclear. Long noncoding RNAs (lncRNAs) have been proven to be playing crucial roles in various biological processes, and emerging studies demonstrated lncRNAs as essential epigenetic modifiers involved in the onset and de...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
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