GSE69715 Infection with Hepatitis C Virus Depends on TACSTD2, a Regulator of Claudin-1 and Occludin Highly Downregulated in Hepatocellular Carcinoma [patient]

Contributors : Vandana Sekhar ; Teresa Pollicino ; Giacomo Diaz ; Ronald E Engle ; Farah Alayli ; Marta Melis ; Juraj Kabat ; Ashley Tice ; Anna Pomerenke ; Nihal Altan-Bonnet ; Fausto Zamboni ; Paolo Lusso ; Suzanne U Emerson ; Patrizia FarciSeries Type : Expression profiling by arrayOrganism : Homo sapiensOur study identifies TACSTD2 as a novel regulator of two major HCV entry factors, CLDN1 and OCLN, which is strongly downregulated in malignant hepatocytes. These results provide new insights into the complex process of HCV entry into hepatocytes and may assist in the development of more efficient cellular systems for HCV propagation in vitro.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research