GSE89829 Anopheles coluzzii larval response to two purified Pseudomonas aeruginosa phenazine pigments 1-HP and Pyo.

Contributors : Philip A Huegli ; Elena A LevashinaSeries Type : Expression profiling by arrayOrganism : Anopheles coluzzii ; Anopheles gambiaePseudomonas aeruginosa, the type species of the Pseudomonas genus, is an environmental Gram negative bacterium, well-known for its ability to produce toxins, resist antibiotics, and opportunistically colonize various niches, including invertebrate and vertebrate hosts. P. aeruginosa produces redox active secondary metabolites called phenazines involved in quorum sensing, biofilm formation, virulence, and iron acquisition. Moreover, these colorful pigmented virulence factors act as ligands for the highly conserved aryl hydrocarbon receptor (AhR) thereby regulating antibacterial defenses in vertebrates. Pseudomonas spp. are some of the most frequently identified bacteria in larval and adult stages of wild mosquito populations. Here we investigated global transcriptional changes induced in A. coluzzii third instar larvae incubated with a sublethal concentration (50 µM) of 1-hydroxyphenazine (1-HP) or pyocyanin (Pyo) at 4 h and 8 h of continuous incubation by whole-genome DNA microarrays.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Anopheles coluzzii Anopheles gambiae Source Type: research