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Prediabetes patients at heightened risk for cardiovascular and chronic kidney diseases

(Emory Health Sciences) Researchers at the Emory Rollins School of Public Health and US Centers for Disease Control and Prevention have found that high proportions of patients with prediabetes are at substantial risk for cardiovascular disease and chronic kidney disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusions: Contrast-enhanced CT upon arrival is suggested, and patients with extravasation on CT would be good candidates for urgent colonoscopy, as well as patients who have a history of CDB and CKD.Digestion 2018;98:41 –47
Source: Digestion - Category: Gastroenterology Source Type: research
Pruritus associated with chronic kidney disease is a distressing condition which has not been rigorously studied using validated patient-reported outcome (PRO) tools. The purpose of this study was to conduct psychometric validation of the Worst Itching Intensity Numeric Rating Scale (NRS), a single item PRO measuring the worst itching severity in the past 24 h on a 0-10-point scale, and to determine the threshold for a clinically meaningful change for this patient population. This analysis was based on data from a phase II randomized, placebo-controlled study which demonstrated the effectiveness of CR845 at reducing modera...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Chronic kidney disease-associated pruritus (CKD-aP) is a debilitating chronic itching condition frequently reported in end stage renal disease patients, with no approved treatments in the United States (US). As the sensation of itching can only be assessed by patient report, reliable, valid and sensitive patient-reported outcomes (PROs) are required to demonstrate treatment benefits in studies of therapies under development for treatment of pruritus in hemodialysis (HD) patients. The purpose of this study was to conduct qualitative interviews in HD patients to evaluate the content validity of two existing PRO instruments, ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Patients with chronic kidney disease are commonly afflicted by pruritus, a condition with no treatment approved in the USA. The etiology of this condition is likely multifactorial, including systemic inflammation and deficiency in the endogenous kappa opioid system. CR845 is a novel and full kappa opioid receptor agonist with no off-target activities, including mu- or delta-opioid receptors. In addition to its unique receptor profile, the peptidic structure of CR845 restricts its entry into the central nervous system.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pharmacology and Drug Development Source Type: research
We thank Dr. Labriola and Dr. Jadoul for their comments.1 We fully agree with the relevance of falls as a major risk factor of fracture in such patients.2 Falls were mentioned and included in Figure  12 as an important determinant of fractures. However, this issue was not extensively discussed because of few relevant data available in chronic kidney disease (CKD) patients. CKD patients, including those treated by dialysis, may have a high propensity for falls. Several factors are probably invo lved, including accelerated aging with deleterious consequences such as impaired cognitive function, neurological disorders, v...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
In their recent review concerning the diagnosis, treatment, and prevention of fractures in chronic kidney disease (CKD) patients, Pimentel et  al.1 point out that the incidence of fractures increases according to CKD stage, with the highest relative risk in patients receiving chronic hemodialysis. The authors underline the high mortality and costs related to fractures in CKD patients and review clinical, biochemical, histological, and st ructural parameters related to bone fragility in CKD. The authors briefly mention but regrettably omit to discuss the occurrence of falls as a crucial determinant for fractures in hemodialysis patients.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
A 44-year-old male patient presented with recurrent urinary tract infections (urine cultures negative) for 2 years. He was diagnosed as having a urethral stricture, and he underwent dilatations. However, his renal functions deteriorated, and he developed chronic kidney disease (CKD) requiring dialysis and transplantation. Pretransplant workup revealed 4 –5 leukocytes on urine examination, proteinuria (0.2 g/d), and a serum creatinine level of 6.7 mg/dl. Magnetic resonance imaging of his kidneys showed multifocal hyperintense lesions in both.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
Patients with rheumatoid arthritis have a higher prevalence of chronic kidney disease than the general population. This is attributed to nephrotoxic drugs and systemic inflammation. Biologic agents have revolutionized the treatment of rheumatoid arthritis. Sumida and colleagues retrospectively examined a large rheumatoid arthritis cohort to determine whether treatment with biologics has improved kidney outcomes. Using propensity matched patients, the incidence of chronic kidney disease and change in estimated glomerular filtration rate was compared in 4000 patients treated with a biologic agent to 4000 patients who were no...
Source: Kidney International - Category: Urology & Nephrology Tags: In This Issue Source Type: research
We thank Fusaro and her colleagues for their comments.1 We concur that there is a sound need for large, well-designed clinical studies to assess the prevalence, risk factors, treatment, and outcome of vertebral fractures in patients with chronic kidney disease (CKD). In our review,2 we did not include quantitative vertebral morphology as assessed by MorphoXpress software to quantify vertebral fractures in CKD. The assessment of vertebral fractures by quantitative vertebral morphology in patients on dialysis and renal transplant recipients resulted in the validation of the tool in osteoporotic patients of the general popula...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
We read with great interest the article by Pimentel et  al.1 on diagnosis, treatment, and prevention of fractures in patients with chronic kidney disease (CKD). We support the message of the clinical relevance of fracture events in CKD, and we would like to add further comments on the issue, such as to stress the need to better study the likely underes timated prevalence of vertebral fractures in CKD. To do so, a systematic population-based screening with spine plain films and morphometric studies of vertebral deformity2 is needed.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
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