Prediabetes patients at heightened risk for cardiovascular and chronic kidney diseases

(Emory Health Sciences) Researchers at the Emory Rollins School of Public Health and US Centers for Disease Control and Prevention have found that high proportions of patients with prediabetes are at substantial risk for cardiovascular disease and chronic kidney disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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AbstractBackgroundStudies in the use of the calcimimetic, cinacalcet, in pediatric chronic kidney disease (CKD) are few and limited to older children with secondary hyperparathyroidism (sHPT), a major morbid complication contributing to poor growth, bone deformities, and cardiovascular disease. Our objectives were to determine a safe and effective dosing regimen of cinacalcet in the treatment of infants and young children with sHPT that was refractory to standard care and to examine their growth during treatment.MethodsTen young pediatric patients with advanced CKD were studied retrospectively during 11 courses of treatmen...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsIn conclusion, a single 0.25  mg/kg dose of cinacalcet was evaluated to be a safe starting dose in these children aged
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
AbstractLife expectancy in patients with all stages of chronic kidney disease (CKD) falls far short of that in the general population. Cardiovascular disease is the leading cause of mortality in pediatric patients with CKD. In contrast to the intimal atherosclerotic lesions that characterize cardiovascular disease in the general population, vascular endothelial dysfunction, medial arterial calcification, and cardiac dysfunction contribute to cardiovascular pathological conditions in CKD. The pathogenesis of these lesions, the origins of which can be identified in the absence of traditional cardiovascular risk factors, is i...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
This study aimed to determine if using additional measures improves the accurate identification of nonadherence beyond provider assessment alone.MethodsEighty-seven adolescents and young adults (AYAs), age 11 –19 years, with chronic kidney disease (CKD) [stage 1–5/end-stage renal disease (ESRD)] and prescribed antihypertensive medication, their caregivers, and 17 medical providers participated in the multisite study. Five adherence measures were obtained: provider report, AYA report, caregiver repo rt, electronic medication monitoring (MEMS), and pharmacy refill data [medication possession ratio (MPR)...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsThe BTP and B2M equations are the worst performing of the eGFR-EPI equations, and no benefit is observed with the addition of BTP or B2M to Cr/cysC.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
The Journal of Clinical Hypertension, EarlyView.
Source: The Journal of Clinical Hypertension - Category: Cardiology Authors: Tags: COMMENTARY Source Type: research
We used electronic health records (EHRs) data from 5658 ambulatory chronic kidney disease (CKD) patients with hypertension and prescribed antihypertensive therapy to examine antihypertensive drug prescribing patterns, blood pressure (BP) control, and risk factors for resistant hypertension (RHTN) in a real ‐world setting. Two‐thirds of CKD patients and three‐fourths of those with proteinuria were prescribed guideline‐recommended renoprotective agents including an angiotensin‐converting enzyme inhibitor (ACEI) or an angiotensin receptor blocker (ARB); however, one‐third were not prescribed an ACEI or ARB. CKD pa...
Source: The Journal of Clinical Hypertension - Category: Cardiology Authors: Tags: ORIGINAL PAPER Source Type: research
Serum fibroblast growth factor 23 (FGF-23) levels are markedly elevated in haemodialysis patients and have been linked to mortality outcomes. Small studies in health and chronic kidney disease, have demonstrat...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Authors: Cucchiari D, Torregrosa JV Abstract Calciphylaxis, also known as calcific uraemic arteriolopathy, is a rare syndrome that typically causes skin necrosis and usually affects dialysis patients. Its pathogenesis is multifactorial and is the consequence of many factors causing ectopic calcifications in patients with chronic kidney disease, such as calcium-phosphate metabolism disorders, hyper- or hypo-parathyroidism, diabetes, obesity, systemic inflammation and the use of vitamin K antagonists, among others. From a clinical point of view, calciphylaxis may progress from painful purpura to extensive areas of sk...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
In conclusion, GTPs exert a therapeutic effect on perglomerular arteriopathy. Our results also revealed a novel mechanism that mediates preglomerular arteriopathy, and suggest GTPs as effective novel renal protective agents. PMID: 30416668 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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