Adenovirus-delivered GFP-HO-1C[INCREMENT]23 attenuates blood–spinal cord barrier permeability after rat spinal cord contusion

In this study, the Ad-GFP-HO-1C[INCREMENT]23 group showed better kinematic functional recovery after SCI than the Ad-GFP and Vehicle groups, as well as smaller reductions in TJ proteins and capillary permeability compared with those in the Ad-GFP and Vehicle groups. These findings indicated that Ad-GFP-HO-1C[INCREMENT]23 might have a potential therapeutic effect that is mediated by its protection of BSCB integrity.
Source: NeuroReport - Category: Neurology Tags: Clinical Neuroscience Source Type: research