Risk Factors Influencing Outcome of Acute Leukemia Patients Who Experience Relapse After Allogeneic Hematopoietic Stem-Cell Transplantation

In a study of 43 patients to assess the risk factors influencing relapse outcome after hematopoietic stem-cell transplantation in acute leukemia, older age and failure to experience complete remission (CR) after treatment were associated with inferior overall survival. Female sex, extramedullary relapse, and absence of postrelapse graft-versus-host disease (GVHD) were associated with lower CR; and absence of extramedullary relapse, treatment with donor lymphocyte infusion, and occurrence of postrelapse GVHD were associated with higher nonrelapse mortality.

Source: Clinical Lymphoma, Myeloma and Leukemia - February 17, 2018 Category: Hematology Authors: Amro M.S. El-Ghammaz, Mostafa K. El-Razzaz Tags: Original Study Source Type: research