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She's tackling a disease that affects 176 million women

Heather Bowerman, a former biotech investor and McKinsey healthcare consultant, is leading a company that developed the first ever non-invasive test for endometriosis, a disease affecting 1 in 10 women and a leading cause of unexplained infertility.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Conclusion: NR4A1 can regulate fibrosis in endometriosis and may serve as a new target for the treatment of endometriosis.Cell Physiol Biochem 2018;46:1078 –1090
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
CONCLUSION: These results provide additional evidence showing that endometriosis symptoms substantially affect the psychological well-being of young patients and identify opportunities for interventions (e.g. cognitive behavioral, rational/emotive therapy) to implement coping styles leading to improved QoL. PMID: 29648907 [PubMed - as supplied by publisher]
Source: Journal of Psychosomatic Obstetrics and Gynaecology - Category: OBGYN Tags: J Psychosom Obstet Gynaecol Source Type: research
Authors: Donnez J, García-Solares J, Dolmans MM Abstract Endometriosis is a frequently encountered benign gynecological disease that may be responsible for infertility. Treatment of endometriosis-associated infertility has been investigated using both medical and surgical therapeutic modalities. Therapy has essentially three main objectives: (i) to preserve and improve fertility, (ii) to reduce pain, and (iii) to delay recurrence. The aim of this paper is to focus on fertility preservation in women with severe endometriosis. In ovarian endometriosis-associated infertility, a medico-surgical approach remains ...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
Publication date: Available online 6 April 2018 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Ioannis Simitsidellis, Douglas A. Gibson, Philippa T.K. Saunders Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation o...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation of models that recapitulate the key features of the disorder. In this review we describe the best-validated animal models (primate, rodent, xenograft) and their contributions to our understanding of the...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Source Type: research
In conclusion, levels of AMH, IGF1 and leptin found in follicular fluid are sensitive markers for anovulatory fertility disorders. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis, fallopian tube damage or disorders with unknown etiology. ABBREVIATIONS: AMH: anti-Müllerian hormone; IGF1: insulin-like growth factor 1; PCOS: polycystic ovary syndrome. PMID: 29595066 [PubMed - as supplied by publisher]
Source: Systems Biology in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Syst Biol Reprod Med Source Type: research
AbstractEndometriosis (EM) is a major cause of infertility and has a complex pathogenesis, which brings severe challenges in both clinical treatment and scientific research. Current clinical research focuses on the difficult problem of improving the pregnancy rate of EM patients. Our studies found that Chinese medicine has significant advantages in terms of improving the pregnancy rate of EM patients.
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
Publication date: Available online 27 March 2018 Source:Reproductive BioMedicine Online Author(s): Xianghui Zhang, Dong Liu, Wei Huang, Qiushi Wang, Xue Feng, Jing Tan The effect of endometriosis on fecundity is unclear. Although surgery plays a vital role in the treatment of related infertility, pregnancy outcomes after laparoscopy are poorly correlated with the currently used staging system. To address this, the Endometriosis Fertility Index (EFI) was developed. This retrospective study was designed to assess the predictive value of the EFI for patients with endometriosis-associated infertility. A total of 1325 patients...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Endometriosis is one of the most common reproductive disorders affecting women. Characterized by the presence of endometrial tissue outside the uterine cavity, it is a heterogeneous disease that can affect different anatomical sites, mainly the ovaries and the peritoneum. All forms of endometriosis cause varying degrees of pelvic pain, dysmenorrhea, dyspareunia, painful defecation, and/or infertility. Although the estimated prevalence of endometriosis is 6% –10% in the general female population, it affects an estimated 35%–50% of infertile women.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Endometriosis is one of the most common reproductive disorders affecting women. Characterized by the presence of endometrial tissue outside the uterine cavity, it is a heterogeneous disease that can affect different anatomical sites, mainly the ovaries and the peritoneum. All forms of endometriosis cause varying degrees of pelvic pain, dysmenorrhea, dyspareunia, painful defecation, and/or infertility. Although the estimated prevalence of endometriosis is 6% –10% in the general female population, it affects an estimated 35%–50% of infertile women.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
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