STIM1 (c)AMPs up melanogenesis

STIM1 and STIM2 are endoplasmic reticulum Ca2+ sensors that serve multi-faceted roles in signal transduction in a wide variety of different cell types. In this issue of The EMBO Journal, Motiani et al define and characterize the ability of STIM1 to control cAMP generation in a new context, melanin production (Motiani et al, 2018), offering new insights into the physiological role of STIM1.

Source: EMBO Journal - March 1, 2018 Category: Molecular Biology Authors: Soboloff, J., Gligorijevic, B., Zaidi, M. R. Tags: Development & Differentiation, Physiology, Signal Transduction News [amp ] Views Source Type: research