Oral Cancer in Fanconi Anemia: Review of 121 cases

Fanconi anemia (FA) is a rare autosomal recessive genetic disorder characterized by aplastic anemia, progressive pancytopenia, congenital anomalies, and increased risk of cancer development. After hematopoietic stem cell transplant (HSCT), patients have an estimated 500-fold increase in the risk of developing head and neck cancer compared to a normal population, and the oral cavity is affected in one-third of cases. Thus, this study aimed to better understand the natural history of oral cavity cancer in patients affected by FA.

Source: Critical Reviews in Oncology Hematology - February 28, 2018 Category: Cancer & Oncology Authors: Camila Pinheiro Furquim, Allana Pivovar, Jos é Miguel Céspedes Amenábar, Carmem Bonfim, Cassius Carvalho Torres-Pereira Source Type: research