Megakaryocyte ontogeny: clinical and molecular significance

• Fetal Mk are phenotypically different than adult Mk• Fetal Mk are matured as adult Mk• Fetal Mk phenotypic features predispose to certain Mk related diseases• Cell intrinsic and extrinsic factors contribute to Mk ontogenic differences• Fetal Mk can be established in adult mode to enhance ex vivo platelets production

Source: Experimental Hematology - February 28, 2018 Category: Hematology Authors: Kamaleldin E. Elagib, Ashton T. Brock, Adam N. Goldfarb Tags: Review Source Type: research