New genetic tools for the in vivo study of hematopoietic stem cell function

• Genetic reporter systems enable prospective identification of bona fide hematopoietic stem cells (HSCs)• Most adult HSCs make a major contribution to steady state hematopoiesis• Minor fraction of stable label-retaining HSCs persists even with age• New roles for mitochondria and metabolic s tate in regulating HSC function in vivo

Source: Experimental Hematology - February 28, 2018 Category: Hematology Authors: Samik Upadhaya, Boris Reizis, Catherine M. Sawai Tags: Review Source Type: research