Anticholinergic Medications and Cognitive Function in Late Midlife.

Anticholinergic Medications and Cognitive Function in Late Midlife. Alzheimer Dis Assoc Disord. 2018 Feb 23;: Authors: Limback-Stokin MM, Krell-Roesch J, Roesler K, Hansen A, Stonnington CM, Temkit M, Caselli RJ, Geda YE PMID: 29481373 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

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Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C8CP07211F, PaperBin Li, Ran Zhang, Xinghua Shi Fibrillation of amyloid peptides induces human diseases such as Alzheimer ’s disease, which has become a huge challenge. Some nanoparticles (NPs) could enhance the peptide fibrillations by decreasing the lag time,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C8CP06971A, PaperAlexander Foote, Lydia H Manger, Michael R Holden, Martin Margittai, Randall H Goldsmith Intrinsically disordered proteins (IDPs) are crucial to many cellular processes and have been linked to neurodegenerative diseases. Single molecules of tau, an IDP associated with Alzheimer ’s disease, are trapped in... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
With the help of artificial intelligence (AI), researchers have developed a...Read more on AuntMinnie.comRelated Reading: Deep-learning algorithm predicts Alzheimer's disease Are amyloid PET scans ready for the clinical setting? PET links amyloid, vascular factors to cognitive decline Artificial intelligence guides lower PET tracer dose Is seeing believing in imaging artificial intelligence?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
While berberine, a traditional Oriental herbal drug commonly used for treatment of diarrhea, has recently been used to treat a number of brain disorders, such as stroke and Alzheimer ’ s disease, berberine-induced changes in hemodynamics are largely unknown. Here, we utilize photoacoustic ...
Source: Applied Optics - Category: Physics Authors: Source Type: research
AbstractAlzheimer ’s disease is a progressive neurodegenerative condition that affects cognition, mental and physical health, and functionality of older people. As the disease progresses from the mild to moderate stage, there is a concomitant increase in several behavioral variables, chiefly agitation, anger, and a ggression. Currently, there are no evidence-based treatments for these behaviors in this population. Three individuals with moderate Alzheimer’s disease were taught an informal mindfulness practice, meditation on theSoles of the Feet (SoF), as a self-management strategy within a multiple-baseline des...
Source: Mindfulness - Category: Psychiatry & Psychology Source Type: research
Bren Research efforts are placing an ever increasing emphasis on identifying signal transduction pathways related to the chemopreventive activity of curcumin. Its anticarcinogenic effects are presumably mediated by the regulation of signaling cascades, including nuclear factor κB (NF-κB), activator protein 1 (AP-1), and mitogen-activated protein kinases (MAPK). By modulating signal transduction pathways, curcumin induces apoptosis in malignant cells, thus inhibiting cancer development and progression. Due to the lack of mechanistic insight in the scientific literature, we developed a novel inverse ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 17 December 2018Source: Progress in Retinal and Eye ResearchAuthor(s): Arthur A. Bergen, Swati Arya, Céline Koster, Matthew G. Pilgrim, Dagmara Wiatrek-Moumoulidis, Peter van der Spek, Stefanie M. Hauck, Camiel J.F. Boon, Eszter Emri, Alan J. Stewart, Imre LengyelAbstractRetinal drusen formation is not only a clinical hallmark for the development of age-related macular degeneration (AMD) but also for other disorders, such as Alzheimer's disease and renal diseases. The initiation and growth of drusen is poorly understood. Attention has focused on lipids and minerals, but relatively ...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
(MedPage Today) -- Certain archived human growth hormone samples can " seed " amyloid-β deposits in the brains of genetically engineered mice
Source: MedPage Today Neurology - Category: Neurology Source Type: news
Conditions:   Alzheimer Disease;   Diabetes Mellitus, Type 2 Intervention:   Device: Tailored Lighting Intervention Sponsors:   Rensselaer Polytechnic Institute;   Icahn School of Medicine at Mount Sinai Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 17 December 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): A.R. Esteves, A.M. Palma, R. Gomes, D. Santos, D.F. Silva, S.M. CardosoAbstractProtein post-translational modifications (PTMs) that potentiate protein aggregation have been implicated in several neurological disorders, including Alzheimer's (AD) and Parkinson's disease (PD). In fact, Tau and alpha-synuclein (ASYN) undergo several PTMs potentiating their aggregation and neurotoxicity.Recent data posits a role for acetylation in Tau and ASYN aggregation. Herein we aimed to clarify the role of ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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