Anticholinergic Medications and Cognitive Function in Late Midlife.

Anticholinergic Medications and Cognitive Function in Late Midlife. Alzheimer Dis Assoc Disord. 2018 Feb 23;: Authors: Limback-Stokin MM, Krell-Roesch J, Roesler K, Hansen A, Stonnington CM, Temkit M, Caselli RJ, Geda YE PMID: 29481373 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

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Publication date: Available online 23 May 2019Source: Pathology - Research and PracticeAuthor(s): Shigehiro Ito, Yasuhiro Miki, Ryoko Saito, Chihiro Inoue, Yoshinori Okada, Hironobu SasanoAbstractAmyloid precursor protein (APP) is a well-known to be involved in the development of Alzheimer's disease and harbors several phosphorylation sites in its cytoplasmic domain. APP has been also proposed as one of the molecules involved in cell proliferation and invasion in several human malignancies. However, the roles of APP including its phosphorylated form (p-APP) have remained largely unexplored in non-small cell lung carcinoma ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Authors: Konstantakopoulos G Abstract There is now general agreement that lack of insight is not merely a fundamental aspect of delusions and hallucinations, or just a symptom of psychotic disorders but rather a multi-dimensional construct. Several different components of insight have been proposed and empirically examined during the last three decades, such as the ability to recognize that one has a mental illness, the capacity to relabel unusual mental events as pathological, the specific attribution of one's symptoms to having a mental illness, awareness of illness' consequences, and compliance with treatment.1 ...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
DiscussionWe empirically identified three neuropsychological subtypes of MCI that share some features with MCI subtypes identified in the Alzheimer's Disease Neuroimaging Initiative. The fourth subtype with SCI in the Mayo Clinic Study of Aging differed from the fourth cluster-derived normal group in Alzheimer's Disease Neuroimaging Initiative and could represent a group to target with early interventions.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
This report presents the most recent nationally representative percentages of adult day services centers (ADSCs) with hospitalizations and chronic conditions by service provision. Service provision may further one or two of the primary goals of adult day services: to reduce the risk of hospitalizations and readmissions, and manage chronic conditions among their participants. Methods-Estimates are from the 2016 Adult Day Services Center survey in the biennial National Study of Long-Term Care Providers conducted by the National Center for Health Statistics. Service provision was measured using scales that included five types...
Source: National health statistics reports - Category: American Health Tags: Natl Health Stat Report Source Type: research
Publication date: Available online 23 May 2019Source: Canadian Journal of CardiologyAuthor(s): Sheng Kang, Jie-Lin PuAbstractLow density lipoprotein receptor related protein 6 (LRP6) is a member of the low density lipoprotein receptors (LDLRs) family and accumulating evidence point to the critical role of LRP6 in cardiovascular health and homeostasis. In addition to present the well-appreciated roles in canonical signaling regulating blood pressure, blood glucose and lipid metabolism, and involved in atherosclerosis, cardiac valve disease, cardiac development, Alzheimer disease and tumorigenesis, LRP6 also inhibits non-can...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
DISCUSSION: For the first time, we demonstrated that the pleiotropic biological effect of the APOE ε4 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may become useful surrogate outcomes for the development of preclinical targeted therapeutic interventions. PMID: 31113760 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
DISCUSSION: Our results encourage an independent validation cohort study to confirm the indication that the plasma Aβ1-40/Aβ1-42 ratio, assessed via Simoa, may improve future standard of care and clinical trial design. PMID: 31113759 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Condition:   Falls (Accidents) in Old Age Interventions:   Behavioral: FallsTalk-C;   Behavioral: FallsTalk Sponsors:   Brookside Research & Development Company;   National Institute on Aging (NIA);   Alzheimer's Association- Washington State Chapter Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
DEMENTIA symptoms can be difficult to sport in its early stages, and they vary from person to person. But, you may be missing one of the earliest warning signs of Alzheimer ’s in your ears. Should you speak to a doctor about dementia symptoms?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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