Muscarinic Receptor-Dependent Long Term Depression in the Perirhinal Cortex and Recognition Memory are Impaired in the rTg4510 Mouse Model of Tauopathy.

In this study, we have examined novel object recognition and PRh LTD in rTg4510 mice, which transgenically overexpress tauP301L. We found that 8-9 month old rTg4510 mice had significant deficits in long- but not short-term novel object recognition memory. Furthermore, we also established that PRh slices prepared from rTg4510 mice, unlike those prepared from wildtype littermates, could not support a muscarinic acetylcholine receptor-dependent form of LTD, induced by a 5 Hz stimulation protocol. In contrast, bath application of the muscarinic agonist carbachol induced a form of chemical LTD in both WT and rTg4510 slices. Finally, when rTg4510 slices were preincubated with the acetylcholinesterase inhibitor donepezil, the 5 Hz stimulation protocol was capable of inducing significant levels of LTD. These data suggest that dysfunctional cholinergic innervation of the PRh of rTg4510 mice, results in deficits in synaptic LTD which may contribute to aberrant recognition memory in this rodent model of tauopathy. PMID: 29484523 [PubMed - as supplied by publisher]
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

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I was on KPCC (NPR) in Los Angeles, yesterday, to address the question "Should Patients Diagnosed With Alzheimer’s Or Dementia Be Able To Choose Assisted Suicide?" A recent op-ed in the L.A. Times titled, “My friend has dementia and wants to end her life. California’s assisted-suicide law excludes her,” shines a light on the complexities of expanding the state’s law beyond patients with a cancer diagnosis or terminal illness. The law, passed in 2015 and modeled after a 1997 Oregon statute, allows physicians to give lethal drugs to mentally competent adults when they’re faced wi...
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