Why Flu Outbreaks Have Been the Worst in Nearly a Decade

The only thing worse than getting the flu is catching it after you’ve gotten a flu shot. It’s been a terrible year for outbreaks — the worst in almost a decade. Contributing to that is the high failure rate of this year’s vaccine. The current shot is just 25 percent effective against the H3N2 virus, this season’s most-often-identified strain by the Centers for Disease Control and Prevention. The experts say, with enough time and money, they can do a lot better. “There has to be a wholesale change to how we make the flu vaccine,” said Amesh Adalja, senior scholar at Johns Hopkins Center for Health Security. “We’re always setting ourselves up for vaccine mismatch and failures and the like because of the lead time in how long it takes the vaccines to be made.” Drug companies and public-health agencies are already grappling with the challenge of next year and beyond. Officials must decide several months ahead of flu season the make-up of the year’s vaccine. Flu shots are typically 40 percent to 60 percent effective in any given season, though this year fell short of that mark. The ultimate goal is a universal vaccine that would operate more like a measles inoculation than a vaccine targeted at a handful of strains of flu. The idea is to offer something closer to 90 percent protection against a disease for years — if not for life — with a single vaccine. It’s still early days. And out-maneuvering ...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Bloomberg flu healthytime onetime Source Type: news

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Authors: Cerveró A, Sedano-Tous MJ, Madera J, López-de-Eguileta A, Casado A Abstract The case concerns a 26-year-old patient with bilateral recurrent optic neuritis episodes in the context of suspected neuromyelitis optica. In the first outbreak, she had greatly impaired visual acuity of the left eye, as well as seeing ganglion cell layer damage in both eyes in the optic coherence tomography, with evidence of a possible extensive lesion in the optic chiasma. Likewise, MRI with contrast showed a great involvement of the left optic nerve that compromises the chiasma increasing the suspicion of a neuromy...
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
With Chinese authorities warning the coronavirus outbreak is accelerating, placing millions of people in more than a dozen Chinese cities under intense travel restrictions might seem like a good idea.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
The number of dead climbed to at least 80, while in the United States, five cases were confirmed.
Source: NYT Health - Category: Consumer Health News Authors: Tags: China Coronavirus (2019-nCoV) Medicine and Health Deaths (Fatalities) Politics and Government Travel and Vacations Lunar New Year Epidemics Viruses Airlifts Hubei Province (China) Wuhan (China) Source Type: news
Residents of China's Hubei province, where the new coronavirus outbreak was first reported, will be banned from entering Hong Kong from Monday as China tries to halt the rapid spread of the outbreak.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
In this study we have genetically modified a serotype 1 strain (519/43), the first time that this has been achieved for this serotype, providing the methodology for a deeper understanding of its biology and pathogenicity. As proof of principle we constructed a defined pneumolysin mutant and showed that it lost its ability to lyse red blood cells. We also showed that when mice were infected intranasally with the mutant 519/43Δply there was no significant difference between the load of bacteria in lungs and blood when compared to the wild type 519/43. When mice were infected intraperitoneally there were significantly f...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study represents the first large scale attempt to gather a long period information on Q fever infection in Greece. The findings of the current study support the fact that Q fever is an important endemic zoonotic disease in Greece and needs increased awareness by clinical physicians and health care system.
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
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Source: Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
AbstractPurpose of ReviewThe widespread incidence of morbidity and mortality associated with opioid use disorder (OUD) has resulted in a national crisis. One component of this public health epidemic includes a lack of an adequately trained healthcare workforce to provide opioid case management, prescribing, and dispensing. The Extension for Community Healthcare Outcomes (Project ECHO) is a tele-mentoring, guided practice model, which provides knowledge exchange from specialists and subspecialists to enable primary care providers and clinicians to deliver best practice care for complex health conditions like OUD. Project EC...
Source: Current Treatment Options in Psychiatry - Category: Psychiatry Source Type: research
ConclusionP. karwinskii leaf extract inhibited reactive oxygen species and exerted an anti-inflammatory effect. Moreover, this extract did not induce gastric damage in the animals. The bioactivity of the species was found to support its traditional use in traditional medicine. This orchid could be used to treat inflammatory diseases without causing the side effects associated with Nonsteroidal anti-inflammatory drugs. It can also be employed to treat other pathological conditions associated with oxidative stress. The findings herein form the basis for the future discovery of natural products that may serve as safe alternat...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 25 January 2020Source: International Journal of PharmaceuticsAuthor(s): Xue Zheng, Chao Sun, Rilei Yu, Xin Chu, Jiahao Xu, Chengcheng Liu, Miaoqing Zhao, Xuelian Xu, Ming Xia, Cheng WangAbstractRelapse in Allergic Rhinitis (AR) is triggered by various unclear mechanisms. Xanthium strumarium L. as a traditional folk medicine can inhibit inflammatory responses through multiple mechanisms. Xanthatin (XT) is a bioactive compound derived from Xanthium strumarium L, and we developed a polymeric micelle (PM) that is dendritic cells (DCs)-specific targeting delivery system loading XT (NGR-XT-PM) ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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