C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance.

Conclusion: C-fos increased the expression of P-gp and mdr1 in the HEp-2/VCR cells, and enhanced the efflux function of the cells, thereby contributing to the development of MDR.
PMID: 29483928 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - February 28, 2018 Category: Biochemistry Authors: Li G, Hu X, Sun L, Li X, Li J, Li T, Zhang X Tags: Cell Mol Biol Lett Source Type: research