Beta cell regeneration can be stimulated in the pancreas

Progenitor cells located in the human pancreas can be primed to become beta cells, potentially becoming a new therapeutic option for type-1 diabetes patients, according to a study inCell Reports.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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CONCLUSIONS: Hybrid procedures are safe and effective both in CLI patients with or without DM, and they should be taken into consideration whenever indications are present. PMID: 30779095 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive pancreatic β cell destruction. The disease is triggered by a combination of genetic and environmental factors, but the mechanisms leading to the triggering of early innate and late adaptive immunity and consequent progressive pancreatic β cell death remain unclear. The insulin-producing β cells are active s ecretory cells and are thus particularly sensitive to endoplasmic reticulum (ER) stress. ER stress plays an important role in the pathologic pathway leading to autoimmunity, islet inflammation, and β ce...
Source: Journal of Innate Immunity - Category: Allergy & Immunology Source Type: research
Condition:   Type 1 Diabetes Mellitus Intervention:   Behavioral: Promoting Resilience in Stress Management (PRISM) Sponsor:   Seattle Children's Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThe application of olesoxime can reduce the stressful condition for the islets in vitro and subsequently improve their viability and functionality.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
(Columbia University's Mailman School of Public Health) Researchers at the Center for Infection and Immunity (CII) at the Columbia University Mailman School of Public Health and the University of New South Wales, Sydney, Australia, provide new evidence supporting an association between elevated levels of enteroviruses in the intestinal tracts of children and islet autoimmunity, a precursor to type 1 diabetes. The paper appears in the journal Scientific Reports.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Diabetes Technology&Therapeutics,Volume 21, Issue S1, Page S-95-S-100, February 2019.
Source: Diabetes Technology and Therapeutics - Category: Endocrinology Authors: Source Type: research
Diabetes Technology&Therapeutics, Ahead of Print.
Source: Diabetes Technology and Therapeutics - Category: Endocrinology Authors: Source Type: research
Diabetes Technology&Therapeutics, Ahead of Print.
Source: Diabetes Technology and Therapeutics - Category: Endocrinology Authors: Source Type: research
Diabetes Technology&Therapeutics,Volume 21, Issue S1, Page S-95-S-100, February 2019.
Source: Diabetes Technology - Category: Endocrinology Authors: Source Type: research
Diabetes Technology&Therapeutics, Ahead of Print.
Source: Diabetes Technology - Category: Endocrinology Authors: Source Type: research
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