Cancer: Fibroblast subtype provides niche for cancer stem cells

Nature Reviews Drug Discovery 17, 163 (2018). doi:10.1038/nrd.2018.23 Author: Megan Cully The role of cancer-associated fibroblasts (CAFs) in tumour formation has been controversial. A new paper in Cell demonstrates that a subset of CAFs, defined by the presence of the cell surface markers CD10 and GPR77, promotes tumour formation and chemoresistance by providing a niche
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research