Chromogranin A levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Chromogranin A (CgA) is a protein found in large dense-core vesicles of neuroendocrine cells and neurons and regulating secretion. A relevance to ALS was suggested as its overexpression accelerates disease onset in model systems and it interacts with mutant forms of SOD1. Recently, increased cerebrospinal fluid (CSF) CgA levels have been reported in ALS patients relative to controls. With the aim of confirming this finding, we measured CgA and phosphorylated neurofilament heavy chain (pNFH), an established ALS biomarker, in the CSF of 32 ALS patients and 32 disease controls.

Source: Neurobiology of Aging - February 27, 2018 Category: Neuroscience Authors: Federico Verde, Petra Steinacker, Patrick Oeckl, Jochen H. Weishaupt, Angela Rosenbohm, Vincenzo Silani, Albert C. Ludolph, Markus Otto Tags: Negative results Source Type: research