Repression of adenosine triphosphate binding cassette transporter ABCG2 by estrogen increases intracellular glutathione in brain endothelial cells following ischemic reperfusion injury

This study was aimed to define the role of ABCG2 in estrogen-mediated neuroprotection against ischemic injury. ABCG2 protein levels before and after ischemic stroke were increased in the brain of female mice by ovariectomy, which were reversed by estrogen replacement.

Source: Neurobiology of Aging - February 27, 2018 Category: Neuroscience Authors: Jin A. Shin, Sae Im Jeong, Hye Won Kim, Gyeonghui Jang, Dong-Ryeol Ryu, Young-Ho Ahn, Ji Ha Choi, Youn-Hee Choi, Eun-Mi Park Source Type: research