Sphingolipid Turnover Turns Over the Fate of Aneuploid Cells.
Sphingolipid Turnover Turns Over the Fate of Aneuploid Cells.
Trends Genet. 2018 Feb 21;:
Authors: Storchová Z
Abstract
Aneuploidy, or unbalanced chromosome number, is a hallmark of cancer. Recently established model systems revealed that aneuploidy affects many aspects of cellular physiology, among them sphingolipid metabolism. The new finding that the proliferation of aneuploid cells depends on sphingolipid homeostasis offers an appealing opportunity for cancer treatment.
PMID: 29477508 [PubMed - as supplied by publisher]
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Storchová Z Tags: Trends Genet Source Type: research