Flubromazolam: a potent designer benzodiazepine
Flubromazolam 3 out of 5 stars Flubromazolam — A new life-threatening designer benzodiazepine. Lukasik-Glebocka M et al. Clin Toxicol 2016;54:66-68. Abstract Last month, the Peoria (IL) Journal-Star reported that local police had seized samples of two rarely seen designer sedatives: flubromazolam (alleged street name “liquid Xanax“) and etizolam. This paper from Poland presents a case report of flubromazolam exposure. A 27-year-old male known to use psychotropic drugs was brought to hospital after being found unconscious at home. On arrival he was comatose with a Glasgow Coma Scale of 3. On exam, he was breathing at rate of 6-8/min and was intubated. He had multiple pressure sores over the right side of his body, as well as hypotonia, hypotension (80/40) and hyporeflexia. He was treated with 1500 ml normal saline. Gelofusine, and pressors. He showed no response to naloxone. Head CT was unremarkable. Creatine kinase was 15,960 U/L and creatinine 1.53 mg/dL (reference 0.7 – 1.4.) Because the urine drug screen was positive for benzodiazepines, flumazenil was administered in doses 0.5 mg with partial improvement in level of consciousness. A second head CT on day 3 showed “hypoxic-ischemic changes within the internal capsules bilaterally.” After the patient’s mental status improved and he could provide history, he reported ingesting flubromazolam “3 mg” purchased over the internet. Specific toxicologic testing confirmed the pre...
Source: The Poison Review - Category: Toxicology Authors: Leon Gussow Tags: Medical benzodiazepine analog designer drug etizolam flubromazolam liquid xanax sedative-hypnotic Source Type: news
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