Inflammatory markers and cortisol parameters across depressive subtypes in an older cohort

There is growing evidence that inflammatory and cortisol dysregulation are underlying pathophysiological mechanisms in the aetiology of major depressive disorder, particularly in younger adults. However, findings of biological disturbances in late-life depression have been divergent, probably due to the even greater heterogeneity of depression in older adults with aging processes influencing biological factors. Using empirically derived subtypes may enable the identification of biological disturbances underlying depression in older adults.

Source: Journal of Affective Disorders - February 27, 2018 Category: Neurology Authors: E.M. Veltman, F. Lamers, H.C. Comijs, M.L. Stek, R.C. van der Mast, D. Rhebergen Tags: Review article Source Type: research