Eritrea:Commendable Health Service Provision
[Shabait] Indicating that owing to the successful villages regrouping people living in the remote areas of the region have become beneficiaries of health services, the head of the Ministry of Health branch in the region, Dr. Yohannes Tekeste said that in the past 26 years the number of health facilities has increased form 5 to 41 and that has increased by 800%.
In this study, we employ Designer Receptor Exclusively Activated by Designer Drugs (DREADDs) together with the mouse 5-Choice Serial Reaction Time Task (5-CSRTT) to investigate the necessary roles of these catecholamines in ADHD-related behaviors, including attention, impulsivity, and motivation. By selective inhibition of tyrosine hydroxylase (TH)-positive VTA dopamine neurons expressing the Gi-coupled DREADD (hM4Di), we observed a marked impairment of effort-based motivation and subsequently speed and overall vigor of responding. At the highest clozapine N-oxide (CNO) dose tested (i.e. 2 mg/kg) to activate hM4Di, we de...
The objectives of the current review are to comprehensively evaluate (1) the potential role of orexins in the pathophysiology of major depressive disorders (MDD) and (2) the orexin system as a novel target in the treatment of MDD. Dysfunction of the sleep-wake cycle is observed as a central feature of MDD pathophysiology. Orexin system disturbances produce sleep-wake dysfunction, as observed in MDD. Orexin antagonists have been shown to treat insomnia effectively without disrupting normal sleep architecture in both preclinical (e.g., animal models) and clinical studies. Orexin antagonists are generally safe, well-tolerated...
ConclusionsOur small-scale experimental study, in which PanoptiqTM was used in the diagnosis of cases that were difficult to diagnose definitively by breast FNA, revealed a positive CB score by every reviewer and the representative diagnosis showed a significant CB. The study suggested that PanoptiqTM could be used for cytopathology consultation.
Anirudh Unni, Klas Ihme, Meike Jipp, Jochem Rieger
Publication date: Available online 18 December 2018Source: Journal of Neuroscience MethodsAuthor(s): Sara J. Aton, Giuseppe Di Giovanni, Nathalie Leresche
ConclusionsThe comparison of spectral properties of binary event signals and permutated event signals is effective in detecting slow oscillatory phenomena.
Publication date: Available online 17 December 2018Source: Journal of Neuroscience MethodsAuthor(s): Armand Mensen, Andrea Pigorini, Laura Facchin, Cornelia Schöne, Sasha D'Ambrosio, Jasmine Jendoubi, Valeria Jaramillo, Kathrin Studer, Aleksandra Eberhard-Moscicka, Simone Sarasso, Antoine Adamantidis, René Müri, Reto Huber, Marcello Massimini, Claudio BassettiAbstractOur own experiences with disturbances to sleep demonstrate its crucial role in the recovery of cognitive functions. This importance is likely enhanced in the recovery from stroke; both in terms of its physiology and cognitive abilities. Decade...
Random drug testing, physician-assisted dying, abortion, and what to do about vaccine refusers are among topics physicians wrestle with daily.Medscape Medical News
Authors: Kakoly NS, Moran LJ, Teede HJ, Joham AE Abstract INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% women of reproductive age. It is associated with a range of metabolic, reproductive, and psychological features. Current evidence indicates a role of PCOS in the development of metabolic and increased cardiovascular risk factors (CVRF) with implications for compromised cardiovascular endpoint disease, which may have a considerable impact on health and health care costs. Areas covered: Existing studies examining long-term cardiometabolic health in PCOS are hetero...
Authors: Ryabets-Lienhard A, Akhtar S, Monzavi R, Austin J Abstract PMID: 30556661 [PubMed - in process]
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