Altered density, composition and microanatomical distribution of infiltrating immune cells in cutaneous squamous cell carcinoma of organ transplant recipients.

CONCLUSIONS: Immune cells infiltrates within SCC and at defined ROI of tumor-surrounding skin in OTR differ markedly in their composition and microanatomical distribution compared to tumors arising in IC. Our findings substantially broaden the understanding of how long-term systemic immunosuppression modulates the local inflammatory microenvironment in the skin and at the site of invasive SCC. This article is protected by copyright. All rights reserved.
PMID: 29479687 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - February 25, 2018 Category: Dermatology Authors: Strobel SB, Safferling K, Lahrmann B, Hoffmann JH, Enk AH, Hadaschik EN, Grabe N, Lonsdorf AS Tags: Br J Dermatol Source Type: research