Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral Probiotic
Lots of you will enjoy this research! MJ J. Agric. Food Chem., Article ASAPDOI:10.1021/acs.jafc.7b05466Publication Date (Web): February 21, 2018 AbstractSeveral benefits have been described for red wine polyphenols and probiotic strains in the promotion of colonic metabolism and health. On the contrary, knowledge about their role in the management of oral health is still scarce. In this work, the antiadhesive capacity of selected red wine polyphenols and oenological extracts against the oral pathogensPorphyromonas gingivalis,Fusobacterium nucleatum, andStreptococcus mutans in an in vitro model of human gingival fibroblasts has been explored as well as their complementary action with the candidate oral probioticStreptococcus dentisani. Results highlighted the antiadhesive capacity of caffeic andp-coumaric acids as well as grape seed and red wine oenological extracts. Both, caffeic andp-coumaric acids increased their inhibition potential againstS. mutans adhesion when combined withS. dentisani. Additionally, UHPLC –MS/MS analysis demonstrated the oral metabolism of wine phenolics due to both, cellular and bacterial activity.