GSE88958 microRNA expression profiling in tumor prostate samples from recurrent and non-recurrent cases

Contributors : Chad Creighton ; Michael Ittmann ; Mustafa Ozen ; Yiqun ZhangSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWe investigated the relative miRNA levels in primary prostate cancer samples from patients that had a subsequent recurrence event versus patients that did not. For one of the top miRNAs arising from this analysis, miR-33a, we carried out further investigation, including miRNA levels in normal and tumor prostate samples as well as PCa cell lines. Then, we performed a detailed functional analysis of mir-33a in LNCaP and VCaP PCa cells and evaluated proliferative, invasive and anchorage independent growth potential of cells upon overexpression and knockdown of miR-33a.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research