Lgals9 deficiency attenuates nephritis and arthritis in pristane ‐induced lupus model of BALB/c mice

ConclusionGalectin‐9 is required for the induction and development of lupus nephritis and arthritis in pristane‐induced mice model of SLE. The current investigation provided a new strategy, in which the antagonism of Galectin‐9 is beneficial for the treatment of nephritis and arthritis in SLE by targeting activated macrophages.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - February 26, 2018 Category: Rheumatology Authors: Sonia Zeggar, Katsue S. Watanabe, Sanae Teshigawara, Sumie Hiramatsu, Takayuki Katsuyama, Eri Katsuyama, Haruki Watanabe, Yoshinori Matsumoto, Tomoko Kawabata, Ken ‐ei Sada, Toshiro Niki, Mitsuomi Hirashima, Jun Wada Tags: Full Length Source Type: research