Inflammation Intensity ‐dependent Expression of Osteoinductive Wnt Proteins is Critical for Ectopic New Bone Formation in Ankylosing Spondylitis

ConclusionsInflammation intensity‐dependent expression of osteoinductive Wnt proteins is a key link between inflammation and ectopic new bone formation in AS. Activation of both canonical Wnt/β‐catenin and noncanonical Wnt/PKCδ pathways is required for inflammation‐induced new bone formation.This article is protected by copyright. All rights reserved.

Source: Arthritis and Rheumatism - February 27, 2018 Category: Rheumatology Authors: Xiang Li, Jianru Wang, Zhongping Zhan, Sibei Li, Zhaomin Zheng, Taiping Wang, Kuibo Zhang, Hehai Pan, Zemin Li, Nu Zhang, Hui Liu Tags: Full Length Source Type: research