Decreased the creatinine to cystatin C ratio is a surrogate marker of sarcopenia in patients with type 2 diabetes

Sarcopenia is a disorder of decreasing skeletal muscle mass and is an important public health problem [1 –3]. Reduced physical activity, underfeeding, decreased hormone production, and chronic inflammation are the known underlying mechanisms [3]. Recent studies have shown that sarcopenia is associated with an increased risk of adverse outcomes, such as physical disability due to falls and bone fractu re, poorer quality of life, and mortality [4,5]. In addition, skeletal muscle is the main consumer of glucose and the main target of insulin activity [6], and it is recognized that low skeletal muscle mass has an adverse impact of on diabetes [7].

Source: Diabetes Research and Clinical Practice - February 26, 2018 Category: Endocrinology Authors: Takafumi Osaka, Masahide Hamaguchi, Yoshitaka Hashimoto, Emi Ushigome, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui Source Type: research