Proof-of-concept study reveals feasibility of eliminating rabies in Africa

(Institut Pasteur) The Swiss Tropical and Public Health Institute, together with European and African collaborators (including the Institut Pasteur in Paris), carried out a mass dog vaccination in Chad and determined its effect on human rabies exposure. The study employed a bio-mathematical method for estimating the transmission dynamics of rabies. The researchers conclude that with political will and the necessary funding, elimination of rabies is possible in Africa.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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AbstractThe mass vaccination of dogs is a proven tool for rabies prevention. Besides parenteral delivery of inactivated vaccines, over the past several decades, several self-replicating biologics, including modified-live, attenuated and recombinant viruses, have been evaluated for the oral vaccination of dogs against rabies. Vaccines are included within an attractive bait for oral consumption by free-ranging dogs. Due to the high affinity between dogs and humans, such biologics intended for oral vaccination of dogs (OVD) need to be efficacious as well as safe. Baits should be preferentially attractive to dogs and not to no...
Source: Veterinary Research - Category: Veterinary Research Source Type: research
Conclusion: RIG-C was well tolerated and provided neutralizing rabies antibodies, which combined with vaccine series after rabies exposure, should result in effective prophylaxis per World Health Organization/Centers for Disease Control and Prevention guidelines. PMID: 29983597 [PubMed]
Source: Clinical Pharmacology: Advances and Applications - Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research
Publication date: Available online 30 June 2018Source: BiologicalsAuthor(s): Zejun Wang, Yan Sun, Xianfu Wu, Darin S. Carroll, Wenli Lv, Lei You, Yaqi Ji, Jinrong Shi, Jiaxin Yan, Gelin Xu, Shengli MengAbstractThe NIH potency test for human rabies vaccines has disadvantages for use, especially in developing countries where rabies is endemic and prophylaxis needs ample, rapid, and reliable vaccine supplies. In China, 60–75 million doses of human rabies vaccines are administered each year. Vaccine quality control is of paramount importance, as is the release of potency-validated vaccines. We intended to design an alter...
Source: Biologicals - Category: Biology Source Type: research
We report on 5 collaborative workshops and 28 semi-structured interviews conducted between January 2017 and June 2018 with: (i) EAL and NPA community members; (ii) Indigenous Rangers in EAL and NPA; and (iii) residents of Cairns, the local regional centre. Storyboard methodologies were used to work with participants and explore what rabies response measures they thought were justified or unacceptable, why they held these views, and what other steps they believed needed to be taken. Key findings include that the capacity of the NPA and EAL communities to contribute/adapt to a biosecurity response is limited by structural di...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 26 June 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Shuo Lei, Xun Gao, Yang Sun, Xiangyong Yu, Longshan ZhaoAbstractA simple method was established for the determination of β-propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30 m×0.32 mm i.d., 0.25 µm) capillary column at the temperature of 80 °C. Electrospray ionization (ESI) was used by selective ion detection at m/z: 42. The temperature for ESI source and inlet was set at...
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research
Publication date: 1 September 2018Source: Preventive Veterinary Medicine, Volume 157Author(s): Hazumu Kadowaki, Phuc Pham Duc, Kazuo Sato, Pham Thi Minh Phuong, Katsuro Hagiwara, Kohei MakitaAbstractRabies is a fatal zoonosis, and in Vietnam, it remains problematic despite the availability of dog rabies vaccination. The purpose of this study was to clarify the socio-economic factors associated with voluntary rabies control measures among the general population using a “Knowledge, Attitudes, and Practice” framework to provide health and veterinary authorities in Vietnam with baseline information for better plann...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Publication date: 1 September 2018Source: Preventive Veterinary Medicine, Volume 157Author(s): Tessa Baker, Susan Kutz, Lorraine Toews, Nicola Edwards, Melanie RockAbstractThe World Health Organization (WHO) and the World Organization for Animal Health (OIE) both recognize the importance of veterinary services in controlling zoonotic diseases, in preventing human injury, and in protecting the welfare of non-human animals. Furthermore, both organizations recommend regular evaluations of veterinary programs. Accordingly, we conducted a scoping review to collate the available peer-reviewed evaluations of subsidized small anim...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Publication date: June 2018Source: International Journal of Veterinary Science and Medicine, Volume 6, Issue 1Author(s): A El-SayedAbstractRabies is a vaccine-preventable fatal disease in man and most mammals. Although rabies is recorded in 150 territories and is responsible for at least 60,000 human deaths every year worldwide, it is a neglected tropical problem. Most of the rabies free countries are considered to be fragile free as the disease may re-emerge easily through wild mammals. For the performance of effective rabies eradication programs, a complex set of strategies and activities is required. At the time, a join...
Source: International Journal of Veterinary Science and Medicine - Category: Veterinary Research Source Type: research
Letter to the editor of Travel Medicine and Infectious Disease.
Source: Travel Medicine and Infectious Disease - Category: Infectious Diseases Authors: Source Type: research
Discussion Vaccines are a mainstay of infectious disease prevention and health promotion. Infants, children and adults benefit from vaccines the most when they are given on the recommended schedules. However there are times when this is not possible as children come to the physician a little early, or a little late, or had unavailable records and so received addition vaccine, etc. There are many questions that arise because of these timing issues such as the one above. Standard vaccine schedules can be reviewed here. Commonly administered vaccines includes: Live-attenuated vaccines Cholera Measles, mumps, rubella (MMR ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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