Two flavonol glycosides from Liparis bootanensis

AbstractTwo new flavonol glycosides, bootanenside  I and II (1 and2), along with ten known compounds (3–12), were isolated from whole plant ofLiparis bootanensis Griff. Their structures were elucidated on the basis of extensive spectroscopic analyses, including high-resolution electrospray-ionization mass spectrometry (HR –ESIMS) and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR). The cytotoxicity of the compounds was investigated against HCT116 human cancer cell line, revealing that none of them possessed considerable cytotoxic activity. Bioassays of the new metabolites showed that compounds1 and2 displayed moderate in  vitro antiinflammatory activity by inhibiting expression of inducible nitric oxide synthase (iNOS) protein in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research