GSE21004 Effects of gene scilencing of USP2 on expression profiles of HL60 cells (PMA 1day and LPS 4hrs)

Contributors : Hiroshi Kitamura ; Masatoshi Ito ; Osamu OharaSeries Type : Expression profiling by arrayOrganism : Homo sapiensSo far, we have found phorbol 12-myristate 13-acetate (PMA) induced ubiquitin specific peptidase (USP) 2b isoform in myeloid leukemia cell lines such as HL60, THP-1, and U937.HL60, THP-1, and U937 undergoes differentiation into macrophage-like cells after stimulation with phorbol ester. To explore molecular function of USP2 in macrophages especially during lipopolysaccharide(LPS) response, we assess expression profiles of HL60-derivatives continuously expressing shRNA for USP2 and control shRNA.

Source: GEO: Gene Expression Omnibus - February 25, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research